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    Abstract
2017 (Vol. 13, Issue: 2)
Research Article

Inhibitory Effect of Polypeptide from Argopecten irradias on Mice with Transplanted H22 Hepatocarcinoma and Its Mechanism

1, 2Yuan Liu, 1Jian Wang, 2Yanan Xia, 2Jianlou Mu, 2Jianfeng Sun and 2Jie Wang
1Department of Food Science, Hebei North University, Zhangjiakou 075000
2College of Food Science and Technology, Agriculture University of Hebei, Baoding 071000, China
 

DOI: 10.19026/ajfst.13.3766
Submitted Accepted Published
October ‎16, ‎2015 January ‎2, ‎2016 February 25, 2017

  How to Cite this Article:

1, 2Yuan Liu, 1Jian Wang, 2Yanan Xia, 2Jianlou Mu, 2Jianfeng Sun and 2Jie Wang, 2017. Inhibitory Effect of Polypeptide from Argopecten irradias on Mice with Transplanted H22 Hepatocarcinoma and Its Mechanism.  Advance Journal of Food Science and Technology, 13(2): 59-67.

DOI: 10.19026/ajfst.13.3766

URL: http://www.maxwellsci.com/jp/mspabstract.php?jid=AJFST&doi=ajfst.13.3766

Abstract:



The objective of this study was to investigate the inhibitory effect of Polypeptide from Argopecten Irradias (PAI) on mice with transplanted H22 hepatocarcinoma. PAI was prepared by enzymatic hydrolysis and separation and the results of its structure identification indicated that it contained five polypeptide components with molecular weights of 700-1000 Da. Forty Kunming mice were randomly divided into H22 hepatocarcinoma group and low, medium and high dose PAI groups. After ig administration of normal saline and different doses of PAI for 10 days, all mice were inoculated with H22 hepatocarcinoma cell suspension to establish models. After continuous gavage for 10 days, the blood was collected from the eyeball and the mice were sacrificed for index detection. It was found that the tumor inhibiting rates of PAI in three dose groups were 28.16, 41.93 and 84.00%, respectively. Compared to H22 hepatocarcinoma group, the mutant serum p53, survivin and MDA levels of mice in three PAI-dose groups were significantly reduced (p<0.01), the IL-2 and SOD levels were significantly increased (p<0.01). The results suggested that PAI had obvious inhibitory effect on mice with H22 hepatocarcinoma cells.

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ISSN (Online):  2042-4876
ISSN (Print):   2042-4868
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