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Abstract
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Article Information:
Study of the Effect of Hydro-Ethanolic Extract of Commiphora africana (Stem-bark) on Inflammation and Pain in Rodents
I. Ezekiel, M.A. Mabrouk and J.O. Ayo
Corresponding Author: Ezekiel Iliya
Submitted: 2009 December, 08
Accepted: 2009 December, 14
Published: 2010 June, 25 |
Abstract:
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Inflammatory response of living bodies is a protective mechanism against infected organisms. The
aim of this study was to evaluate the effect of hydro-ethanolic extract of Commiphora africana (stem-bark) on
inflammation and pain. The anti-inflammatory activity was investigated using the rat paw edema model. The
analgesic activity was studied using the acetic acid induced writhings in mice. The results showed that the
hydro-ethanolic (stem-bark) extract of Commiphora africana possess significant (p<0.05) anti-inflmmatory
effect and inhibit abdominal constriction caused by acetic acid in mice. The results of the preliminary
phytochemical screening of Commiphora africana (stem bark) extract revealed the presence of flavonoids,
tannin, anthraquinone, cardiac glycosides, triterpenoids, saponins, alkaloids and reducing sugars. The LD50 was
calculated as 3708.7 mg/kg in rats and 471.2 mg/kg in mice. It was concluded that the plant is or may be a very
good source of analgesic.
Key words: Analgesic, anti-inflammatory, Commiphora africana, phytochemical screening, , ,
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Abstract
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Cite this Reference:
I. Ezekiel, M.A. Mabrouk and J.O. Ayo, . Study of the Effect of Hydro-Ethanolic Extract of Commiphora africana (Stem-bark) on Inflammation and Pain in Rodents. Asian Journal of Medical Sciences, (3): Page No: 81-84.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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