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Abstract
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Article Information:
Effect of Chronic Oral Administration of Chloroquine on the Histology of the Liver in Wistar Rats
A.M. Izunya, A.O. Nwaopara, L.C. Anyanwu, M.A.C. Odike, G.A. Oaikhena, J.K. Bankole and O. Okhiai
Corresponding Author: Al-Hassan M. Izunya
Submitted: 2010 June, 27
Accepted: 2010 July, 04
Published: 2011 August, 05 |
Abstract:
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The effect of chronic oral administration of chloroquine, an antimalarial and antirheumatic drug on
the histology of the liver in wistar rats was investigated. Ten wistar rats were randomly grouped into two,
control and treated. The treated group rats were administered 20 mg/kg body wt, weekly of chloroquine for
4 weeks while the control group rats were given distilled water for 4 weeks. On day 29th of the experiment,
the rats were weighed and sacrificed by cervical dislocation. The livers were carefully dissected out and quickly
fixed in 10% formal saline for histological studies. The histological findings after H and E methods indicated
that the treated sections of the liver showed cytoplasmic vacuolation; nuclear enlargement and vesiculation of
the hepatocytes when compared with the control. Thus, our result suggests that though chloroquine may be a
widely used antimalarial and antirheumatic drug, its chronic administration may have a deleterious effect on
the liver of wistar rats and by extension may affect its function. It is therefore recommended that the drug be
prescribed with caution in patients with history of liver disease.
Key words: Antimalarial, chloroquine, hepatotoxicity, histology, wistar rats, ,
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Abstract
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Cite this Reference:
A.M. Izunya, A.O. Nwaopara, L.C. Anyanwu, M.A.C. Odike, G.A. Oaikhena, J.K. Bankole and O. Okhiai, . Effect of Chronic Oral Administration of Chloroquine on the Histology of the Liver in Wistar Rats. British Journal of Pharmacology and Toxicology, (3): 97-103.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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