|
Abstract
|
Article Information:
Phytochemical Characterization and in-vivo Anti-Malaria Activity of Lantana camara Leaf Extract
Gabi Baba, A.A.J. Adewumi and V.O. Aina
Corresponding Author: Gabi Baba
Submitted: May 07, 2011
Accepted: July 18, 2011
Published: December 20, 2011 |
Abstract:
|
The characteristic multi-drug resistant strains of Plasmodium to the existing anti-malaria has
increase the global threat of malaria, couple with the wide medicinal application of Lantana camara in
different countries and the literature of its use as anti-microbial, antifungal and insecticidal agents, and the
quest for alternative anti-malaria this work look into the phytochemical screening, characterization and the
In-vivo anti-malaria activity of the Lantana camara leaf extracts. The leaf extracts from plant were screened
for phytochemicals and further FTIR characterized to correlate the routine qualitative phytochemical
screening. In-vivo anti-plasmodia screening was carried out using 24 Swiss albino mice under laboratory
conditions. The effectiveness of the aqueous and ethanolic extracts from the plant (L. camara) was compared
with standard drug Chloroquine. The result indicated the presence of Alkaloids, Cardiac glycosides and
Saponins in the Petroleum ether, aqueous and ethanolic extracts. Carbohydrate in both aqueous and ethanolic
extracts, while Flavonoids and steroids in petroleum ether and ethanolic extracts. Tannins and terpenoids were
present in aqueous and ethanolic extracts respectively. The identified phytochemicals correlate with FTIR
spectral analysis from the identified characteristic functional groups. In-vivo study showed that Chloroquine
was 83% effective in clearing the parasites, while aqueous and ethanolic extracts were 38 and 76% effective
respectively. The curative capacity indicated possible concentration and time-dependency. The ethanolic
extract showed higher level of anti-malaria potential and has indicated some level of protection.
Key words: Anti-Malaria activity , FTIR spectral, Lantana camara, phytochemicals, , ,
|
|
Abstract
|
PDF
|
HTML |
|
Cite this Reference:
Gabi Baba, A.A.J. Adewumi and V.O. Aina, . Phytochemical Characterization and in-vivo Anti-Malaria Activity of Lantana camara Leaf Extract. British Journal of Pharmacology and Toxicology, (6): 277-282.
|
|
|
|
 |
ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
 |
| Information |
|
|
|
|
| Sales & Services |
|
|
|
|
