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Abstract
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Article Information:
Antioxidant Effect of Carica papaya on Ethanol Induced Gastric Lesion in Adult Male Wistar Rats
A.A. Okesina, S.B. Mesole, J. Olusakin, Y.G. Mohammed, A.A. Mohammed, M.O. Buhari, J.O. Ashaolu, I. Ezekiel, A.D.T. Goji and E.A. Caxton-Martins
Corresponding Author: A.A. Okesina
Submitted: June 02, 2011
Accepted: December 09, 2011
Published: June 30, 2012 |
Abstract:
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This study was performed to elucidate the role of some important constituents of antioxidant defence
such as Glutathione Peroxidase (GPx), Thiobarbituric Acid Reaction (TBAR), the activity of the enzyme
Glucose-6-Phosphate Dehydrogenase (G-6-PDH) of Carica papaya on ethanol induced gastric lesion in adult
male wistar rats. Twenty-four male adult Wistar rats weighing 180- 220 g were used in this study. Animals were
divided into three groups (n = 8 per group). The control group A received phosphate buffered saline orally, with
the aid of a cannula. 1 mL of 50% ethanol was administered orally, by a cannula, to produce the gastric lesion
in group B (n = 8). And in the group C, 500 mg/kg body weight of paw paw leaf extract was administered
orally, with a cannula, twelve hours after ethanol administration to the rats. This experiment lasted for twenty
one consecutive days. The result showed that TBARS in gastric mucosa as an index for oxidative stress level
was significantly increased after ethanol administration. CPL did not reduce significantly the levels of TBARS
in the gastric mucosa. G-6-PDH activity was significantly increased in gastric mucosa after ethanol
administration, but in rats treated with CPL, a reverse of G-6-PDH activity was observed. Ethanol induced a
remarkable and significant decrease of GPx activity in gastric mucosa, whereas CPL induced a significant
reversion of ethanol’s effect on the enzyme. The results therefore demonstrate that CPL treatment exerts
antioxidant effects on ethanol-induced gastric lesions in wistar rats.
Key words: Carica papaya (CPL), enzyme, glucose-6-phosphate dehydrogenase (G6PDH), glutathione peroxidase (GPx), stomach, thiobarbituric acid test (TBARS),
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Cite this Reference:
A.A. Okesina, S.B. Mesole, J. Olusakin, Y.G. Mohammed, A.A. Mohammed, M.O. Buhari, J.O. Ashaolu, I. Ezekiel, A.D.T. Goji and E.A. Caxton-Martins, . Antioxidant Effect of Carica papaya on Ethanol Induced Gastric Lesion in Adult Male Wistar Rats. British Journal of Pharmacology and Toxicology, (3): 98-101.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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