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Abstract
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Article Information:
The Antimicrobial Activity of Ethanol Extract of Thymus vulgaris on Salmonella typhi in Rabbets
Sabiha Sharif Salih
Corresponding Author: Sabiha Sharif Salih
Submitted: April 07, 2012
Accepted: June 23, 2012
Published: August 25, 2012 |
Abstract:
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The aim of this study was in vivo antimicrobial activity of ethanol extract of Thymus vukgaris on
Salmonella typhi isolated from patients in Sulaymani city, Iraq. Thirty Salmonella entereca serova typhi were
isolated from blood of patients suffering from typhoied fever in indor and outdor of Sulaymani city-Iraq. The
isolates were identified through cultural, morphological and biochemical examination, in addition to API20E
system. Susceptibility test to eleven antimicrobials were performed for all isolates. The isolates were grouped to 7
antibiogram; The S. enterica isolates were 100% resist to Amp, Cef, Chl, Gm, Tet and Tri antibiotics, or resist to at
least one more antibiotics. The Minimum Inhibition Concentration (MIC) of ethanol extract for Thymus vulgaris
was determined (2500 μg/mL). Treating local rabbits (WBC count of 3000-4000) with MIC of T. vulgaris extract,
after orally infected with more resistant isolate S. typhi S5, and appearance of disease septum with decreasing of
WBC count and lymphocyte, while neutrophil increased for all groups. After treating the infected rabbits with
combination of plant extract and Gentamycin after two month from infection, the numbers of survived rabbits were
more than other treatments.
Key words: Antimicrobial , in vivo ethanolic extract, Salmonella typhi, Thymus vulgaris, , ,
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Abstract
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Cite this Reference:
Sabiha Sharif Salih, . The Antimicrobial Activity of Ethanol Extract of Thymus vulgaris on Salmonella typhi in Rabbets. British Journal of Pharmacology and Toxicology, (4): 147-150.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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