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Abstract
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Article Information:
Modulation of the Antidiabetic Effect of Glimepiride by Diazepam in Diabetic Rats
W.R. Mohamed, G.A. El Sherbiny, H.F. Zaki and M.E. El Sayed
Corresponding Author: W.R. Mohamed
Submitted: March 08, 2012
Accepted: March 30, 2012
Published: October 25, 2012 |
Abstract:
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Anxiolytic drugs may influence glycemic control in diabetic subjects, so the present study was
conducted to investigate the effect of glimepiride, a commonly used oral hypoglycemic, diazepam, a commonly
used anxiolytic, and their combination in STZ-induced diabetic rats. Diabetes was induced by streptozotpcin
(50 mg/kg i.p.). Rats were divided into 5 groups namely: normal control, diabetic control, glimepiride (10
mg/kg p.o.), diazepam (5 mg/kg i.p.) or combination of both glimepiride and diazepam, respectively. All groups
received daily treatments for 2 weeks including the normal group which received 1% Tween 80. Diazepam
significantly improved the effect of glimepiride on the levels of serum glucose, insulin, C-peptide and liver
glycogen content. In addition, combination of diazepam with glimepiride significantly improved the effect of
the latter on oxidative stress biomarkers including serum lipid peroxides, blood glutathione levels and blood
superoxide dismutase activity of diabetic rats. In conclusion, the present study revealed that diazepam increased
the antidiabetic and the antioxidant actions of glimepiride which may be of considerable value in the treatment
of diabetes mellitus where both reduction of associated anxiety and tight glycemic control are needed.
Key words: Anxiety,, diabetes, diazepam, glimepiride, insulin, oxidative stress,
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Cite this Reference:
W.R. Mohamed, G.A. El Sherbiny, H.F. Zaki and M.E. El Sayed, . Modulation of the Antidiabetic Effect of Glimepiride by Diazepam in Diabetic Rats . British Journal of Pharmacology and Toxicology, (5): 190-196.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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