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Abstract
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Article Information:
Effect of Aqueous-Methanolic Stem Bark Extract of Acacia polyacantha on Blood Glucose Levels on Normoglycemic Wistar Rats
A.O. Okpanachi, A.D.T. Goji, I. Ezekiel, K.Y. Musa, Y. Tanko, A. Mohammed and A.B. Adelaiye
Corresponding Author: A.O. Okpanachi
Submitted: July 07, 2011
Accepted: September 09, 2011
Published: June 15, 2012 |
Abstract:
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This study was carried out to investigate the blood glucose reducing effect (hypoglycemic effect)
of stem bark extract of Acacia polyacantha on normal wistar rats over a 24 h period. Three groups of previously
fasted wistar rats, with each group made up of 5 rats each were administered with 100, 200 and 400 mg/kg p.o
of aqueous methanolic stem bark extract of A. polyacantha. The hypoglycemic effect of A . polyacantha stem
bark aqueous methanolic extract was compared with that of Metformin (250 mg/kg) in fasted normal rats.
Following treatment, relatively moderate to high doses of A. polyacantha (100, 200 and 400 mg/kg p.o.)
produced a dose-dependent, significant reduction (p<0.05) in blood glucose levels of fasted normal rats. The
three doses of the extract did not significantly alter the blood glucose levels after 2 h of extract administration.
After 8 and 16 h of extract administration at a dose of 200 mg/kg significantly (p<0.05) decreased the blood
glucose levels when compared to control, while the dose of 400 mg/kg significantly decreased the blood
glucose levels after 4, 8 and 16 h of extract administration when compared with the control group. The
Preliminary phytochemical screening revealed the presence of alkaloids, tannins, flavonoids, triterpenoids,
anthraquinones, steroids and saponins. The median lethal dose (LD50) in rats was calculated to be 3807.9 mg/kg
body weight. In conclusion the aqueous methanolic extract of Acacia polyacantha possesses hypoglycemic
activity in normoglycemic rats.
Key words: Acacia polyacantha, hypoglycemic effect and phytochemical screening, , , , ,
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Cite this Reference:
A.O. Okpanachi, A.D.T. Goji, I. Ezekiel, K.Y. Musa, Y. Tanko, A. Mohammed and A.B. Adelaiye, . Effect of Aqueous-Methanolic Stem Bark Extract of Acacia polyacantha on Blood Glucose Levels on Normoglycemic Wistar Rats. International Journal of Animal and Veterinary Advances, (3): 163-166.
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ISSN (Online): 2041-2908
ISSN (Print): 2041-2894 |
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