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Abstract
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Article Information:
Effect of the Aqueous Root Extract of Urena lobata (Linn) on the Liver of Albino Rat
I.Y. Mshelia, B.M. Dalori, L.L. Hamman and S.H. Garba
Corresponding Author: Sani H Garba
Submitted: September 13, 2010
Accepted: October 14, 2010
Published: January 01, 2013 |
Abstract:
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The effects of the aqueous root extract of urena lobata on the rat liver was investigated using a total of (25)
adult Wister rats of both sexes that were randomly divided into five groups of five rats each. Group I served as the
control, while rats in groups II-IV where administered 100, 200 and 300 mg/kg body weight of the extract, respectively
for 28 days. Rats in group V were administered 300 mg/kg of the extract for 28 days and allowed to stay for 14 days post
treatment to observe for reversibility, persistence or delayed occurrence of toxic effects. At the end of the experimental
period the animals were sacrificed and liver weight taken and fixed for routine histological examinations. Administration
of the extract to rats had no effects on liver and body weights but the extract caused a decrease in albumin level and
increases in the levels of Aspartate Transaminases (AST), Alanine Transaminases (ALT) and Alkaline Phosphatase
(ALP). Histopathological assessment of the liver revealed mild to severe interstitial hemorrhage, mononuclear cell
infiltration, necrosis, congestion and edema in the liver of the treated rats while withdrawal of the extract for 14 days
showed a slight degree of recovery in the rats. This findings suggest that the biochemical and morphological organization
of the liver can significantly be altered with continues and increase use of the extract, but further studies on the long term
effect of the extract and a prolonged recovery period is recommended in further studies.
Key words: Congestion, edema, interstitial hemorrhage, mononuclear cell infiltration, necrosis, urena lobata,
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Cite this Reference:
I.Y. Mshelia, B.M. Dalori, L.L. Hamman and S.H. Garba, . Effect of the Aqueous Root Extract of Urena lobata (Linn) on the Liver of Albino Rat. Research Journal of Applied Sciences, Engineering and Technology, (01): 01-06.
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ISSN (Online): 2040-7467
ISSN (Print): 2040-7459 |
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