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Abstract
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Article Information:
Possible Reversal of Sodium Arsenate-induced Liver Toxicity by Hexane Leaf Extract of Alchornea laxiflora
Uhunmwangho S. Esosa, Omage Kingsley, Erifeta O. Georgina, Josiah J. Sunday and Nwangwu C.O. Spencer
Corresponding Author: Omage Kingsley
Submitted: July 24, 2012
Accepted: August 28, 2012
Published: February 25, 2013 |
Abstract:
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This research was aimed at evaluating the anti-toxicity potentials or properties of A. laxiflora Thus, the possible reversing effect of sodium arsenate-induced liver toxicity by hexane leaf extract of Alchornea laxiflora was investigated using adult wistar albino rats weighing between 150-200 g as experimental model. Oral administration of the extract at varying doses (0.5, 1.0, 5.0 and 10.0 mg/kg body weight) was shown to significantly (p<0.05) decrease the effect of sodium arsenate-induced liver damage by reducing the activities of AST, ALT, ALP, GGT and TB, both in the serum and liver homogenate. Pre-treatment with the extract prior to the intra-peritoneal administration of the toxicant (sodium arsenate) at a dose of 2 mg/kg body weight was shown to be more effective at reversing the effect of the toxicant than post-treatment with the extract after intoxication. Thus, the ability of Alchornea laxiflora leaf extract to protect against sodium arsenate induced liver damage by possible reversal of arsenic toxicity suggests that this plant extract might be suitable for the treatment of sodium arsenate toxicity.
Key words: Alchornea laxiflora, hexane, liver homogenate, serum enzymes, sodium arsenate, toxicity,
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Cite this Reference:
Uhunmwangho S. Esosa, Omage Kingsley, Erifeta O. Georgina, Josiah J. Sunday and Nwangwu C.O. Spencer , . Possible Reversal of Sodium Arsenate-induced Liver Toxicity by Hexane Leaf Extract of Alchornea laxiflora. Asian Journal of Medical Sciences, (1): 3-8.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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