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Abstract
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Article Information:
Effect of Ethanolic Leaf Extract of Mucunapruriens (fabaceae) on Lipid Profile inAlloxan-Induced Diabetic Wistar rats
E.D. Eze, A. Mohammed, K.Y. Musa, Y. Tanko and A.S. Isa
Corresponding Author: E.D. Eze
Submitted: November 14, 2011
Accepted: December 20, 2011
Published: June 30, 2012 |
Abstract:
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Diabetes mellitus is a global health burden leading to an increase in the search for herbal
hypoglycemic agents as alternative to synthetic ones. The effect of diabetes on lipid metabolism is well
established. This study was aimed at evaluating the effects of ethanolic leaf extract of M. pruriens on lipid
profile levels in alloxan-induced diabetic Wistarrats. Diabetes was induced by injection of Alloxan
monohydrate (150 mg/kg b w) intraperitoneally to rats. Diabetic rats were randomly divided into the following
groups (n = 6). Group I (normal control) received distilled water, Group II (diabetic control) received distilled
water, group III, IV and V received 100, 200 and 400 mg/kg b w of the extract, respectively, while group VI
received 250 mg/kg b w Metformin orally once daily for 21 days. At the end of the treatment period, blood
samples were collected from the animals and assayed spectrophotometrically for serum concentration of TC,
TG, HDL-C and LDL-C. The study showed that there was a significant reduction (p<0.05) in the serum levels
TC, TG, LDL-C and increased HDL-C in alloxan-induced diabetic treated groups.However, there was a marked
reduction (p<0.01) of 96.86±10.6, 106.31±7.5, 48.09±11.0 observed in the groups treated with 400 mg/kg for
TC, TG, LDL-C. While a maximum increase (p<0.01) of 23.01±1.8 and 28.52±0.90 recorded in the group
treated with 200 and 400 mg/kg for HDL-C. The result shows that the plant may be useful in the management
of secondary complications of diabetes (dyslipidemia) associated with diabetes mellitus.
Key words: Allloxan, diabetes mellitus, dyslipidemia, lipid profile, metformin, Mucunapruriens,
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Cite this Reference:
E.D. Eze, A. Mohammed, K.Y. Musa, Y. Tanko and A.S. Isa, . Effect of Ethanolic Leaf Extract of Mucunapruriens (fabaceae) on Lipid Profile inAlloxan-Induced Diabetic Wistar rats. British Journal of Pharmacology and Toxicology, (3): 102-109.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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