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Abstract
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Article Information:
Histological Effects of Oral Administration of Artesunate on the Liver in Wistar Rats
A.M. Izunya, A.O. Nwaopara, A. Aigbiremolen, M.A.C. Odike, G.A. Oaikhena and J.K. Bankole
Corresponding Author: Al-Hassan M. Izunya
Submitted: May 13, 2010
Accepted: May 29, 2010
Published: 2010 July, 10 |
Abstract:
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This experiment was designed to study the histological effects of oral administration of normal and
double normal doses of artesunate on the histology of the liver in wistar rats. The rats were divided into three
groups (A, B and C ) of five rats each. A and B served as the treatment groups, while C served as the control
group. Group A rats were given 4 mg/kg b.w of artesunate daily for 3 days followed by 2 mg/kg b.w daily for
next for 4 days. Group B rats were given 8 mg/kg2 b.w of artesunate daily for 3 days followed by 4 mg/kg b.w
daily for next 4 days, while group C rats were given only distilled water. The rats were fed with grower's mash
purchased from Edo feeds and Flour M ill Ltd, Ewu, Edo state and were given water ad libitum. On day eight
of the experiment, the rats were weighed and sacrificed by cervical dislocation. The livers were carefully
dissected out and quickly fixed in 10% formal saline for histological studies. The histological findings after H
and E method showed sinusoidal congestion with cytoplasmic vacuolation (hepatocyte oedema) and mild
inflammation of the portal tracts. Our study suggests that artesunate at normal dose has a toxic effect on the
liver cells and could be a potential hepatotoxic drug. It is therefore recommended that further studies aimed
at corroborating these observations be carried out and self-medication with artesunate should be discouraged.
Key words: Antimalarial, artesunate, liver histology, toxicity, , ,
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Cite this Reference:
A.M. Izunya, A.O. Nwaopara, A. Aigbiremolen, M.A.C. Odike, G.A. Oaikhena and J.K. Bankole, . Histological Effects of Oral Administration of Artesunate on the Liver in Wistar Rats. Research Journal of Applied Sciences, Engineering and Technology, (4): Page No: 314-318.
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ISSN (Online): 2040-7467
ISSN (Print): 2040-7459 |
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