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Abstract
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Article Information:
Chronic Oral Administration of Ethanol Extract of Carica papaya Seeds Does not Affect the Histology of the Cauda Epididymis of Adult Male Wistar Rats
Wilson O. Hamman, Sunday A. Musa, Daniel T. Ikyembe, Uduak E. Umana, Alexander B. Adelaiye, Andrew J. Nok and Samuel A. Ojo
Corresponding Author: Wilson Oliver Hamman
Submitted: 2011 June, 28
Accepted: 2011 August, 27
Published: 2011 October, 25 |
Abstract:
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The role of the epididymis in male reproduction has been studied and it is well established that the
spermatozoa are produced by the germinal epithelia of seminiferous tubules and are transported to the
epididymis for onward transport, maturation and storage. The antifertility property of Carica papaya seed
extracts have also been well documented in experimental animals. This study examines the effect of chronic
oral administration of ethanol extract of C. papaya on the histology of adult male wistar rats. 15 apparently
healthy adult male wistar rats were obtained from the animal house of the Department of Human Anatomy,
Ahmadu Bello University Zaria and divided into 3 groups (I, II, III) of 5 each. 100 and 250 mg/kg/day of the
extract was orally administered to groups II and III, respectively while group I which served as control received
distilled water. The daily administration was carried out for a period of 90 days after which the animals were
humanely sacrificed, the epididymis obtained and processed for light microscopy. Microscopic examination
of the epididymis showed normal histology in both the control and experimental groups. This study concludes
that the oral administration of the extract which has great potential in male fertility control does not affect the
histology of the epididymis of adult male wistar rats.
Key words: Carica papaya seed, cauda epididymis, chronic oral administration, histology, , ,
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Cite this Reference:
Wilson O. Hamman, Sunday A. Musa, Daniel T. Ikyembe, Uduak E. Umana, Alexander B. Adelaiye, Andrew J. Nok and Samuel A. Ojo, . Chronic Oral Administration of Ethanol Extract of Carica papaya Seeds Does not Affect the Histology of the Cauda Epididymis of Adult Male Wistar Rats. Asian Journal of Medical Sciences, (5): 192-194.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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