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Abstract
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Article Information:
Changes in Lipid Profile of Aqueous and Ethanolic Extract of Blighia sapida in Rats
O.A. Owolabi, D.B. James, A.B. Ibrahim, O.F. Folorunsho, I. Bwalla and F. Akanta
Corresponding Author: Dorcas B James
Submitted: 2010 April, 16
Accepted: 2010 May, 04
Published: 2010 August, 30 |
Abstract:
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Aqueous and ethanolic leaf extracts of Blighia sapida was assessed for som e lipid profile parameters
in normal albino rats. Daily administration of the extracts (50 and 100 mg/kg body weight) for 21days showed
that the extract significantly (p<0.05) reduced the levels of total cholesterol, triglycerides and LDL-cholesterol
in all the treated groups when compared with the control. While significantly (p<0.05) higher value was
observed for the HDL-cholesterol of all the treated groups when compared with the control, this effect was
observed as dose dependent for aqueous extract. For the atherogenic indices, there was a significant (p<0.05)
increase in HDL-cholesterol/Total cholesterol ratio, while LDL-cholesterol/HDL-cholesterol and log (TG/HDLCH)
ratio showed a significant (p<0.05) decrease in treated groups compared to the control group. These
findings may be of clinical importance to individuals at risk of cardiovascular disease.
Key words: Aqueous extract, antherogenic indices, Bligha sapida, ethanolic extract, lipid profiles, ,
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Cite this Reference:
O.A. Owolabi, D.B. James, A.B. Ibrahim, O.F. Folorunsho, I. Bwalla and F. Akanta, . Changes in Lipid Profile of Aqueous and Ethanolic Extract of Blighia sapida in Rats. Asian Journal of Medical Sciences, (4): Page No: 177-180.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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