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Abstract
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Article Information:
Mercury Chloride-Induced Glucose Intolerance in Rats: Role of Oxidative Stress
A.O. Morakinyo, B.O. Iranloye, G.O. Oludare, O.J. Oyedele and O.O. Ayeni
Corresponding Author: A.O. Morakinyo
Submitted: 2011 December, 16
Accepted: 2011 January, 08
Published: 2012 February, 20 |
Abstract:
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Mercury is recognized as a hazardous environmental and industrial pollutant; however it is
commercially important in many industries/applications. This has therefore led to an increase in occupational
and environmental exposures in many parts of the world. The present study evaluated the impact of mercury
chloride on glucose homeostasis and the possible involvement of oxidative stress. In addition, the potential
protective effects of Alpha Lipoic Acid (ALA), a naturally occurring and unique antioxidant on mercury
chloride toxicity were investigated. Thirty rats were randomly divided into five equal groups of six animals:
Group 1 (control) received 0.5 mL distilled water; Group 2 (ALA) received 100 ug/kg of ALA; Group 3 (LDM)
and Group 4 (HDM) received 250 and 500 ug/kg body weight of HgCl2, respectively; and Group 5 (HDMALA)
received 500 ug/kg body weight of HgCl2 simultaneously with 100 ug/kg of ALA. Both HgCl2 and ALA
were administered orally for 14 consecutive days. The fasting blood glucose was measured and all groups were
subjected to Oral Glucose Tolerance Test (OGTT). In addition, the activities of reduced glutathione, superoxide
dismutase, catalase as well as the level of lipid peroxidation were estimated. The results showed significant
adverse changes in glucose tolerance and oxidative indices in rats exposed to mercury chloride. However,
treatment with ALA attenuated all mercury triggered changes. This study clearly demonstrates the induction
of glucose intolerance by mercury chloride and suggests the involvement of oxidative stress as an important
regulator of glucose homeostasis during mercury chloride exposure.
Key words: Antioxidants and lipid peroxidation, diabetes mellitus, glucose tolerance, mercury chloride, oxidative stress, ,
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Abstract
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Cite this Reference:
A.O. Morakinyo, B.O. Iranloye, G.O. Oludare, O.J. Oyedele and O.O. Ayeni, . Mercury Chloride-Induced Glucose Intolerance in Rats: Role of Oxidative Stress. British Journal of Pharmacology and Toxicology, (1): 7-12.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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