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Abstract
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Article Information:
Evaluation of Anti-Inflammatory, Analgesic and Antipyretic Effects of Azadrichcta indica Leaf Extract on Fever-Induced Albino Rats (Wistar)
O.J. Olorunfemi, D.C. Nworah, J.N. Egwurugwu and V.O. Hart
Corresponding Author: O.J. Olorunfemi
Submitted: December 20, 2011
Accepted: Jaurauy 26, 2012
Published: April 25, 2012 |
Abstract:
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The present study was carried out to investigate the anti-inflammatory, antipyretic and analgesic
effect of the crude ethanol extract of Azadirachta indica leaves on experimental rat model at three different dose
levels- 100, 200 and 300 mg/kg, respectively. Hot plate test were used to assess analgesic activity, formalin
induced inflammation was used for anti-inflammatory study and baker’s yeast was used to induce pyrexia.
Acute toxicity test was also performed in rats after administration of the extract orally at high dose level
(4 g/kg). In addition, ethanol extract obtained from Azadirachta indica leaves at different doses and different
periods of study showed significant effect (p<0.05) compared to control. For analgesic study, the extract at 100
mg/kg showed a slow but time dependent effect, at 200 mg/kg, its effect was noticed in all the periods although
still time dependent and at 300 mg/kg, the effect was significant in all the periods and long-lasting at the final
minutes (90 min) with values expressed in mean±SEM of 14.0±1.41 which was significant (*p<0.05) compared
to control and all other groups. The anti-inflammatory study of the ethanolic extract of Azadirachta indica
showed a time and dose dependent effect at different periods. It’s effect was noticed in all doses but was most
significant (**p<0.05) in group 4 which was given 300 mg/kg of the extract with a value of 40.6±8.80 expressed
in mean±SEM compared to control and all other groups. The extract at all dose showed significant effect
(*p<0.05) over control. Its effect was time and dose-dependent. However, the extract attenuated the pain, fever
and inflammation induced in the rats at 100, 200 and 300 mg/kg, respectively dose levels but its significant
protective effect was noticed at higher doses than low doses and at a longer period of time. In acute toxicity
study, no mortality was observed at 4 g/kg dose level.
Key words: Albino wistar rats, analgesic, anti-inflammatory, anti-pyretic, Azadirachta indica, baker’ yeast, fever
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Cite this Reference:
O.J. Olorunfemi, D.C. Nworah, J.N. Egwurugwu and V.O. Hart, . Evaluation of Anti-Inflammatory, Analgesic and Antipyretic Effects of Azadrichcta indica Leaf Extract on Fever-Induced Albino Rats (Wistar). British Journal of Pharmacology and Toxicology, (2): 49-53.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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