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Abstract
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Article Information:
The Effect of Aqueous Extract of Leaf of Ficus capensis Thunb (Moraceae) on in Vivo Leukocyte Mobilization in Wistar Rats
O.A. Daikwo, J.A. Tende, S.M. Okey, E.D. Eze and A.S. Isa
Corresponding Author: O.A. Daikwo
Submitted: December 20, 2011
Accepted: January 02, 2012
Published: June 30, 2012 |
Abstract:
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Immune system (the body’s defense system which protects the body from diseases), is subject to
modification by substances to either enhance or suppress its ability to resist invasion by pathogen. Ficus
capensis Thunb. (Moraceae), a wild fig tree, is believed by the Igala people of Kogi State in Nigeria to possess
an immune boosting property, hence, forming part of most of their traditional remedies for several ailments.
This study was aimed at investigating, so as to ascertain this claim. Twenty wistar strain albino rats divided into
four groups of five animals each were used. One hour prior to introduction of an inflammatory stimulus, each
rat in groups (Group 2-4) received oral administration of 100, 150 and 250 mg/kg, respectively of aqueous
extract of leaf of Ficus capensis Thunb (Moraceae). The control group (Group 1) received distilled water. After
four hours, the animals were sacrificed and both Total and Differential Leukocyte Counts were performed on
the peritoneal fluid obtained from these animals. Evaluation of the data obtained from this study indicated a
significant (p<0.05) dose-dependent increase in leukocyte mobilization, with doses 150 and 250 mg/kg giving
total leukocyte count of 4.44±0.39×109 and 6.10±0.86×109/L, respectively, the most mobilized being
Neutrophils. The results obtained from this study suggest that the extract might have a pharmacologically active
substance which may be responsible for the above effect and its applications in traditional medicines as an
immune boosting agent.
Key words: Ficus capensis thumb, immunity, inflammation, leukocytes mobilization, peritoneum, ,
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Cite this Reference:
O.A. Daikwo, J.A. Tende, S.M. Okey, E.D. Eze and A.S. Isa, . The Effect of Aqueous Extract of Leaf of Ficus capensis Thunb (Moraceae) on in Vivo Leukocyte Mobilization in Wistar Rats. British Journal of Pharmacology and Toxicology, (3): 110-114.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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