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Abstract
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Article Information:
Change in Organs Weight and Antioxidant Potential of Combined Effects of Aqueous Extracts of Phyllanthus amarus and Vitex doniana Stem Bark on Streptozotocin-Induced Dibetic Rats
D.B. James, O.A. Owolabi, A.O. Oluloto, H. Mohammed and O.A. Muhammed
Corresponding Author: D.B. James
Submitted: 2011 September, 23
Accepted: 2011 November, 04
Published: 2011 December, 25 |
Abstract:
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Phyllanthus amarus and Vitex doniana are used folklore plants in several disorders due to their
excellent properties and potent phyto-constituents. In this study, change in organs weight and antioxidant
potential of combined effects of aqueous extracts of Phyllanthus amarus and Vitex doniana stem bark on
streptozotocin - induced diabetic rats was investigated. In a 21 days study, animals were divided into six groups
(A- F) of six rats each. Group A served as normal control, group B as diabetic control, Groups C, D and E were
administered with three different plant extracts (100 mg/kg of Phyllanthus amarus, Vitex doniana and
combination of the two plants repectively, group F was treated with standard drug insulin (5 units/kg).
Administration of Vitex doniana extracts and Phyllanthus amarus and their combination significantly (p<0.05)
decrease fasting blood glucose. Significant (p<0.05) increase in weight gain for animals in treated groups when
compared with diabetic group was observed. Treated groups significantly (p<0.05) decrease levels of
thiobarbituric acid (TBARS), while catalase and Superoxide Dismutase (SOD) in liver and kidney were
significantly (p<0.05) increase when compared with diabetic control group. Phyllanthus amarus treated groups
shows significantly (p<0.05) higher SOD in the liver and kidney when compared with standard drug. While
kidney catalase was significantly (p<0.05) higher in the groups treated by Vitex doniana and Phyllanthus
amarus compared with other treated group. These results suggest that the use of aqueous extract of these plants
and their combination possess antidiabetic and antioxidant activity, which could exert a beneficial action against
the disease associated with free-radicals complications.
Key words: Antioxidant, aqueous extracts, albio rats, catalase, diabetes, Phyllatus amarus, polytherapy, superoxide dismutase, Vitex doniana
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Cite this Reference:
D.B. James, O.A. Owolabi, A.O. Oluloto, H. Mohammed and O.A. Muhammed, . Change in Organs Weight and Antioxidant Potential of Combined Effects of Aqueous Extracts of Phyllanthus amarus and Vitex doniana Stem Bark on Streptozotocin-Induced Dibetic Rats. Asian Journal of Medical Sciences, (6): 237-242.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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