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Abstract
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Article Information:
Evaluation of Hepatoprotective Activity of Argemone mexicana Aerial Part Extracts on CCL4 Induced Liver Damage in Wistar Rats
S.I.Y. Adam, I.A. Idris, E.H. Abdelgadir, R.H. Ahmed and E.E. Kamal
Corresponding Author: Shama Adam
Submitted: 2011 August, 08
Accepted: 2011 September, 25
Published: 2011 November, 25 |
Abstract:
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This study is carried out on Wistar rats to evaluate the hepatoprotective activity of Argemone
mexicana L aerial part extracts against CCL4 induced acute liver damages. The areal part of the plant was
extracted by methanol and water using soxhlet, rotary evaporator and freeze drying apparatus. Hepatic injury
was achieved by injecting 3 mL/kg s.c. of CCL4 in equal volume proportion with olive oil. The aqueous and
methanol extracts of Argemone mexicana areal part were given at different doses, 100, 200, 400 mg/kg/day
Methanol extract, and 400 mg/kg/day orally of aqueous extract for 5 days under CCL4 induction at 3rd day. The
significance of differences between means was compared among the groups using Independent-sample T-test
with probability value. The methanol extract at 100 mg/kg offered significant hepatoprotective activity (p<0.05)
by reducing the serum marker enzyme, like Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum
Glutamate Pyrovate Transaminase (SGPT) and Alkaline Phosphatase (ALP). Histopathlogical studies further
confirmed the hepatoprotective activity of 100 mg/kg methanol extract. Argemone mexicana L. at dose 100
mg/kg indeed has a reasonable potential in healing liver parenchyma and regeneration of liver cells hence it
may acts as a potent liver tonic. The results obtained were compared with silymarin (70 mg/kg.oral), the
standard drug, which shown recovery toward normalization almost like that of silymarin, therefore, we
recommend for further studies to isolate the pure component and the mechanism that displayed the
hepatoprotective activity for making standard drug.
Key words: Hepatotoxicity, papaveraceae, phyllanthus species, silymarin, soxhlet, ,
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Abstract
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Cite this Reference:
S.I.Y. Adam, I.A. Idris, E.H. Abdelgadir, R.H. Ahmed and E.E. Kamal, . Evaluation of Hepatoprotective Activity of Argemone mexicana Aerial Part Extracts on CCL4 Induced Liver Damage in Wistar Rats. British Journal of Pharmacology and Toxicology, (5): 251-256.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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