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Abstract
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Article Information:
Effects of Antioxidant Vitamin Combination on Electrolyte Status in Pregnancy
O.I. Iribhogbe, J.E. Emordi, B.O. Idonije, U. Akpamu, E.O. Nwoke and A. Aigbiremolen
Corresponding Author: Osede Ignis Iribhogbe
Submitted: 2010 December, 09
Accepted: 2011 January, 03
Published: 2011 February, 10 |
Abstract:
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It is a known fact that hypertension is associated with pregnancy. Several studies have reported a
link between hypertension and a shift in serum electrolyte concentration. This study is designed to investigate
the effect of antioxidant vitamin A, C and E bi- combination on electrolyte status in pregnancy. In a bid to
investigate the above objective, varying combination of antioxidant vitamin A, C and E were administered to
70 pregnant Wister albino rats. These were assigned into two control groups treated with distilled H2O and
vehicle- tween-80 respectively and three cohorts (I, II and III) with four sub-groups each (n = 5). Beginning
from the 7th day, test group I received a varying dose combination of vitamin A+C, group II vitamin A+E, and
group III vitamin C+E respectively for 11 days. Results revealed a non significant reduction (p>0.05) in serum
Na+ and Ca2+, and a significant change p<0.05) in serum Cl- and K+ following Vit A+C administration when
compared with control. The group treated with Vit A+E combination presented a non significant change in
serum Na+, Cl-, K+ and Ca2+ level. Vit C+E treated group presented a significant reduction (p<0.05) in serum
Na+, K+ and Ca2+ with no alteration in serum Cl-. In conclusion, antioxidant vitamin A, C and E bi-combination
ameliorates the reported high Na+ concentration in pregnancy and may be of significance as adjuvants in the
management of hypertension in pregnancy. However, the importance of further research cannot be
overemphasized.
Key words: Antioxidants, bi-combination, electrolytes, hypertension, pregnancy, synergistic, vitamins
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Abstract
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Cite this Reference:
O.I. Iribhogbe, J.E. Emordi, B.O. Idonije, U. Akpamu, E.O. Nwoke and A. Aigbiremolen, . Effects of Antioxidant Vitamin Combination on Electrolyte Status in Pregnancy. British Journal of Pharmacology and Toxicology, (1): 21-26.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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