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Abstract
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Article Information:
Ameliorative Effects of Vitamin C and Zinc in Alloxan-induced Diabetes and Oxidative Stress in Wistar Rats
F.A. Dawud, E.D. Eze, A.A. Ardja, A.S. Isa, A. Jimoh, M. Bashiru and I.S. Malgwi
Corresponding Author: F.A. Dawud
Submitted: 2011 September, 29
Accepted: 2011 November, 04
Published: 2012 March, 10 |
Abstract:
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This study was undertaken to evaluate the ameliorative effects of vitamin C and zinc on blood
glucose levels and lipid peroxidation in Alloxan-induced diabetic Wistar rats. Diabetes was induced in animals
by intraperitoneal injection of Alloxan monohydrate (150 mg/kg b w). Diabetic rats were randomly divided into
three groups (n = 5): Rats in group I were given 1ml of distilled water and served as the control. Rats in group
II and group III were administered 100 50 mg/kg b w of vitamin C and zinc respectively. The regimens were
given once daily for seven days. Blood samples collected from the animals at the end of the treatment period
and assayed for malonaldehyde (MDA) as index of lipid peroxidation. The study showed that there was a
significant (p<0.05) decrease in the blood glucose levels of 206.40±33.71, 115.80±14.75, 204.20±55.93 and
125.80±25.44, 118.0±9.55, 123.60±31.71, with Vitamin C 100 mg/kg and zinc 50 mg/kg respectively when
compared to control group. Alloxan induced group showed an increased concentration of Malondialdehyde
(MDA) of 3.16±0.98. However, there was a significant reduction (p<0.05) in Malondialdehyde concentration
in the group that received 50 mg/kg b w of zinc, while no significant change (p>0.05) was observed in the
group that were administered 100 mg/kg b w of vitamin C when compared to the diabetic control group. The
present study has shown that vitamin C and zinc had a beneficial effect on Alloxan induced hyperglycemia and
oxidative stress as evidenced by decreased malondialdehyde (MDA) concentration.
Key words: Alloxan, diabetes mellitus, malondialdehyde, oxidative stress, vitamin C, zinc,
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Cite this Reference:
F.A. Dawud, E.D. Eze, A.A. Ardja, A.S. Isa, A. Jimoh, M. Bashiru and I.S. Malgwi, . Ameliorative Effects of Vitamin C and Zinc in Alloxan-induced Diabetes and Oxidative Stress in Wistar Rats. Current Research Journal of Biological Sciences, (2): 123-129.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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