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Abstract
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Article Information:
Anti-Lipidimic and Anti-Hyperglycemic Properties of Methanolic Extract of Grape Seed in Diabetic rats
Zohre Ganjali, Fereshteh Javadian, Jasem Estakhr and Abbas Heidari
Corresponding Author: Farzaneh Shakeri
Submitted: January 14, 2012
Accepted: February 17, 2012
Published: June 15, 2012 |
Abstract:
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The aim of this study was to assess the effect of methanolic grape seed extract on the blood glucose
and lipid profile in diabetic rats. For this research 30 male adult rats were randomly selected and divided into
three groups as nondiabetic control; diabetic control; diabetic rats treated with methanolic extract of grape seed.
In diabetic groups, alloxan monohydrate (120 mg/kg) was injected intraperitoneally to develop diabetes. Then
the Test group received intraperitoneal injection of methanolic extract of grape seed (100 mg/kg). At last,
glucose, cholesterol, triglyceride, HDL, VLDL, LDL and insulin contents of the rats' serum sample were
determined. Diabetic rats treated with extract showed a significant decrease in blood glucose level (p<0.05).
There was a significant decrease in serum contents of total cholesterol (TC), LDL, VLDL and TG, but a
significant increase in insulin level and HDL of extract-treated group was observed in compare with diabetic
group (p<0.05). These results show that the methanolic extract of Grape Seed may be effective in the treatment
of diabetes. This effect may be due to the presence of flavonoides and antioxidant properties of grape seed.
Key words: Grape seed, blood sugar, lipid profile, insulin, , ,
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Cite this Reference:
Zohre Ganjali, Fereshteh Javadian, Jasem Estakhr and Abbas Heidari, . Anti-Lipidimic and Anti-Hyperglycemic Properties of Methanolic Extract of Grape Seed in Diabetic rats. International Journal of Animal and Veterinary Advances, (3): 173-175.
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ISSN (Online): 2041-2908
ISSN (Print): 2041-2894 |
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