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Abstract
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Article Information:
Synthesis, Physico-Chemical and Antimicrobial Properties of Co(II), Ni(II), and Cu(II) Mixed-Ligand Complexes of Dimethylglyoxime
A.A. Osunlaja, N.P. Ndahi, J.A Ameh and A. Adetoro
Corresponding Author: A.A. Osunlaja
Submitted: 2011 July, 22
Accepted: 2011 September, 08
Published: 2011 November, 25 |
Abstract:
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The synthesis of non-electrolyte mixed-ligand complexes of the general formula [M(Hdmg)B], where
M = Co(II), Ni(II) or Cu(II) Hdmg = dimethylglyoximato monoanion, B = 2- aminophenol(2-aph), diethylamine
(dea) or malonic acid (MOH) are described. Metal analysis, melting points, solubility, conductivity, IR and
UV/Visible electronic spectra were used in determining their physico-chemical properties. The antimicrobial
activities of the complexes were tested against Esherichia coli, Staphylococcus aureus, Aspergillus niger and
Aspergillus flavus. The complexes melted/decomposed at 120-306ºC and, most of them dissolved only in polar
solvents. The colours of the complexes are mostly dark - brown or red. The spectral results suggest the binding
of Hdmg, 2-amino phenol or malonic acid through the N atom and O atoms respectively to the metal ion In the
electronic spectra of the complexes, the absorption bands observed in the UV/Visible region are presumed to
be either due to charge transfer or intra-ligand transitions from the ligands or d-d transitions from the metal
ions. The complexes showed marked antimicrobial activity against the tested microbes at 10 mg/mL. The
possible use of the complexes as chemotherapeutic agents is hereby suggested.
Key words: Antimicrobial activity, dimethylglyoxime, infrared spectroscopy, mixed - ligand, UV/Visible spectroscopy, ,
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Cite this Reference:
A.A. Osunlaja, N.P. Ndahi, J.A Ameh and A. Adetoro, . Synthesis, Physico-Chemical and Antimicrobial Properties of Co(II), Ni(II), and Cu(II) Mixed-Ligand Complexes of Dimethylglyoxime. Research Journal of Applied Sciences, Engineering and Technology, (11): 1233-1238.
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ISSN (Online): 2040-7467
ISSN (Print): 2040-7459 |
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