|
Abstract
|
Article Information:
Protective Effects of Alpha Lipoic Acid on Carbon Tetrachloride-Induced Liver and Kidney Damage in Rats
A.O. Morakinyo, G.O. Oludare, A.A. Anifowose and O.A. Adegoke
Corresponding Author: A.O. Morakinyo
Submitted: 2011 December, 20
Accepted: 2011 January, 12
Published: 2012 February, 20 |
Abstract:
|
Carbon tetrachloride (CCl4) is a well known toxicant and exposure to this chemical is known to
induce oxidative stress by the formation of free radicals. The present study investigates the in vivo effects of
alpha lipoic acid (ALA) on CCl4-induced hepatic and renal toxicities. Twenty-four Sprague-Dawley rats were
divided into four groups of 6 animals each and treated for 10 consecutive days. Group 1 was given olive oil
only. Group 2 received CCl4 intra-peritoneally (i.p.) at a dose of 0.8 mg/kg as a 30% olive oil solution. Group
3 was given ALA only at a dose 25 mg/kg. Group 4 was given both CCl4 and ALA, respectively. At the end
of experiment, the antioxidant status in both the liver and kidney tissues were estimated by determining the
activities of antioxidant enzymes; reduced glutathione, superoxide dismutase, catalase as well as the level of
lipid peroxidation via thiobarbituric reactive substance. The liver and kidney functions tests were also
performed in addition to their histopathological evaluation. Results obtained showed significant adverse
changes in the levels of all measured parameters in CCl4 treated rats. However, treatment with ALA attenuated
the adverse changes in the CCl4-induced rats. Our findings suggest that ALA protects the liver and kidney
against CCl4-induced damage through its significant effects on the antioxidant activities.
Key words: Alpha lipoic acid, antioxidants, carbon tetrachloride, hepatotoxicity, nephrotoxicity, oxidative stress,
|
|
Abstract
|
PDF
|
HTML |
|
Cite this Reference:
A.O. Morakinyo, G.O. Oludare, A.A. Anifowose and O.A. Adegoke, . Protective Effects of Alpha Lipoic Acid on Carbon Tetrachloride-Induced Liver and Kidney Damage in Rats. British Journal of Pharmacology and Toxicology, (1): 21-28.
|
|
|
|
 |
ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
 |
| Information |
|
|
|
|
| Sales & Services |
|
|
|
|
