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Abstract
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Article Information:
Some of the Regenerative Properties of the Aqueos Extract of Ocimum sanctum on the Cytoarchitecture of the Liver of Adult Female Wistar Rats Following Paracetamol Induced Liver Damage
S.B. Mesole, Y.G. Mohammed, C. Nyaribo, J. Olusakin and A.O. Okpanachi
Corresponding Author: S.B. Mesole
Submitted: May 18, 2012
Accepted: June 15, 2012
Published: October 25, 2012 |
Abstract:
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The aim of the present study is to investigate some of the regenerative properties of Ocimum sanctum on
the cytoarchitecture of the liver of adult female wistar rats following paracetamol induced liver damage. There is a
lack of good hepatoregenerative drugs in modern medicine to aleviate and treat drug-induced liver damage. Leaves
of sacred holy basil, also called Green Tulsi (Ocimum sanctum), belonging to family Lamiaceae are used
traditionally for their hepatoregenerative effect. We wanted to evaluate the hepatoregenerative activity of Ocimum
sanctum on paracetamol induced liver damage among female adult waster rats. At the end of this research which
lasted for 14 days, remarkable and appreciable improvement was noticed in the appearance of the cytoarchitecture of
the liver and reduction in sinusoidal congestion, cloudy swelling and fatty changes and regenerative areas of the
liver were observed on histopathological examination in groups of the liver of group II and III that was administered
variable dosage of the extract as compared to the group I which displayed only hepatic necrosis. We concluded from
the result of our research that aqueous extract of Ocimum sanctum shows hepatoregenerative activity.
Key words: Cytoarchitecture, hepatic necrosis, hepatoregenerative, liver damage, Ocimum sanctum, paracetamol,
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Cite this Reference:
S.B. Mesole, Y.G. Mohammed, C. Nyaribo, J. Olusakin and A.O. Okpanachi, . Some of the Regenerative Properties of the Aqueos Extract of Ocimum sanctum on the Cytoarchitecture of the Liver of Adult Female Wistar Rats Following Paracetamol Induced Liver Damage . British Journal of Pharmacology and Toxicology, (5): 230-232.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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