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Abstract
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Article Information:
Behavioural Effects of Hydro-methanolic Crude Extract of Aerial Part of Indigofera pulchra in Mice
Y. Tanko, I. Ezekiel, A.O. Okpanachi, A.D.T. Goji, H. Ndebi, K.Y Musa and A. Mohammed
Corresponding Author: Tanko,Yusuf
Submitted: 2009 June, 29
Accepted: 2009 July, 07
Published: |
Abstract:
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Indigofera pulchra is used traditionally as prophylactic against snake-bite, treatment of infected
wounds and as anti-inflammatory. In this study, the behavioural effects of hydromethanolic of the aerial part
extracts of Indigofera pulchra were investigated in mice. The results revealed that the extract significantly
(p< 0.05) prolonged the onset and reduced the duration of sleep at the dose tested (200mg/kg). The extract
significantly (p<0.05) increased exploratory activity at the dose tested (400mg/kg). It produced no significantly
motor coordination deficits in mice at the doses tested (100,200 and 400mg/kg). The intraperitoneal median
lethal dose in mice was 2,154 mg/kg while the preliminary phytochemical screening revealed the presence of
tannins, saponins, steroids and flavonoids. This result suggests that hydromethanolic extract of Indigofera pulchra might contains biologically active principles that are stimulative in nature and lend pharmacological credence to the ethnomedical use of the plant.
Key words: Indigofera pulchra, diazepam, behavioral, motor coordination, , ,
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Abstract
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Cite this Reference:
Y. Tanko, I. Ezekiel, A.O. Okpanachi, A.D.T. Goji, H. Ndebi, K.Y Musa and A. Mohammed, . Behavioural Effects of Hydro-methanolic Crude Extract of Aerial Part of Indigofera pulchra in Mice. Current Research Journal of Biological Sciences, (3): Page No: 89-93.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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