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Abstract
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Article Information:
Changes in Lipid Profile of Rats Administered with Ethanolic Leaf Extract of Mucuna pruriens (Fabaceae)
E.D. Eze, A. Mohammed, K.Y. Musa and I.S. Malgwi
Corresponding Author: Eze, Ejike Daniel
Submitted: 2011 October, 12
Accepted: 2011 November, 18
Published: 2012 March, 10 |
Abstract:
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The study evaluated the effect of ethanolic leaf extract of Mucuna pruriens on some lipid profile
parameters of normoglycemic Wistar rats. The acute oral toxicity studies were conducted. The animals were
administered with the plant extract at graded doses of 100, 200 and 400 mg/kg b w and metformin 250 mg/kg
bw orally for 21 days. Blood samples were collected from the animals at the end of the treatment period and
assayed for the serum concentration of total cholesterol, triglyceride, low-density lipoprotein and high-density
lipoprotein cholesterol. The results showed the extract significantly reduced (p<0.05) the levels of serum total
cholesterol, triglyceride, low-density lipoprotein and elevated high-density lipoprotein in the groups treated with
100 and 200 mg/kg b w. There was no significant changes (p>0.05) in the lipid profile in the group treated with
400 and 250 mg/kg b w of metformin. In conclusion, the results of the present findings may be beneficial and
of clinical importance to individuals at risks of cardiovascular problems.
Key words: Cardiovascular disease, ethanolic exract, lipid profile, metformin, Mucuna pruriens, ,
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Cite this Reference:
E.D. Eze, A. Mohammed, K.Y. Musa and I.S. Malgwi, . Changes in Lipid Profile of Rats Administered with Ethanolic Leaf Extract of Mucuna pruriens (Fabaceae). Current Research Journal of Biological Sciences, (2): 130-136.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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