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Abstract
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Article Information:
Evaluation of Effect of Ethanolic Leaf Extract of Mucuna pruriens on Blood Glucose Levels in Alloxan-Induced Diabetic Wistar Rats
E.D. Eze, A. Mohammed, K.Y. Musa and Y. Tanko
Corresponding Author: Eze, Ejike Daniel
Submitted: 2011 October, 16
Accepted: 2011 November, 23
Published: 2012 February, 25 |
Abstract:
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Mucuna pruriens is used extensively for its medicinal value for the treatment of diabetes mellitus
in Nigeria. This study investigated the anti-diabetic activity of Mucuna pruriens on the blood glucose levels
and the histopathology of the pancreas. To achieve this, Acute toxicity studies of the plant extract was
determined. Doses of 100, 200 and 400 mg/kg bw of the extract were administered orally daily for 21 days to
alloxan-induced diabetic Wistar rats. Metformin was used as a standard anti-diabetic drug and given by gavage.
The fasting blood glucose levels were determined at intervals of three days. Premininary phytochemical
screening revealed the presence of flavonoids, saponin, tannins, cardiac glycosides, triterpenes and reducing
sugars. The LD50 of the extract of Mucuna pruriens was found to be 2154 mg/kg. The study showed that there
was a significant reduction (p<0.05) in the fasting blood sugar levels in alloxan-induced diabetic treated groups
that received 100, 200 and 400 mg/kg of the extract orally, with a maximum reduction (p<0.01) of 161.83±18.2,
153.67±13.8 and 133.83±10.4 recorded in the groups treated with 100, 200 and 400 mg/kg. The
histopathological studies of the pancreas of diabetic animals revealed the degeneration of pancreatic Islet cells,
but with the restoration of pancreatic Islet cells in the pancreas of diabetic group treated with various doses of
the plant extract. The implications of the results obtained in the present study provide the scientific rationale
for the use of Mucuna pruriens as anidiabetic agent.
Key words: Alloxan, blood glucose, diabetes mellitus, metformin, Mucuna pruriens, pancreas,
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Cite this Reference:
E.D. Eze, A. Mohammed, K.Y. Musa and Y. Tanko, . Evaluation of Effect of Ethanolic Leaf Extract of Mucuna pruriens on Blood Glucose Levels in Alloxan-Induced Diabetic Wistar Rats. Asian Journal of Medical Sciences, (1): 23-28.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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