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Abstract
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Article Information:
Ascorbic Acid Ameliorates Toxic Effects of Chlopyrifos on Testicular Functions of Albino Rats
Kolawole Victor Olorunshola, L.N. Achie and M.L. Akpomiemie
Corresponding Author: K.V. Olorunshola
Submitted: 2011 September, 02
Accepted: 2011 October, 07
Published: 2011 November, 25 |
Abstract:
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Chlorpirifos (CPF) is a widely used organophosphate insecticide for both agricultural and domestic
purposes with attendant human exposures. Many authors have documented the toxic effects of CPF on the
central nervous system. This study was designed to study the effect of CPF and the influence of coadministration
of ascorbic acid (AA) on the testicular functions of albino rats. Twenty five 2 months old male
albino wistar rats were divided into 5 groups of 5 rats each (Group A-E). A (control) received vegetable oil,
B received 16.3 mg/kg CPF, C received 32.6 mg/kg CPF, D received 16.3 mg/kg CPF + AA 100 mg/kg and
E received 32.6 mg/kg CPF + AA 100 mg/kg. Treatment was orally for a duration of 21 days. Thereafter, body
weight, serum testosterone, testicular, epididymal and seminal vesicle weight, epididymal sperm concentration,
sperm motility and histopathology of the testis, epidydimis and seminal vesicles were determined using
standard methods. CPF caused a statistically significant change (p<0.05) in body weight, testicular weight,
epididymal weight, sperm concentration, sperm motility and serum testosterone concentration. Seminal vesicle
weight was not affected. Histopathological studies revealed reduced sperm reserve, fibrosis and fatty infiltration
in the epididymis, seminiferous tubules and seminal vesicles respectively. Co-administration of AA
significantly caused improvement in all the parameters measured. It is concluded that CPF caused testicular
toxicity by possible oxidative stress which was reversed with co-administration of AA.
Key words: Ameliorative effects, atrophy, chlopyrifos toxicity, epididymis, insecticide, rats, seminal vesicle, serum testosterone, testicular functions and vitamin C
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Cite this Reference:
Kolawole Victor Olorunshola, L.N. Achie and M.L. Akpomiemie, . Ascorbic Acid Ameliorates Toxic Effects of Chlopyrifos on Testicular Functions of Albino Rats. British Journal of Pharmacology and Toxicology, (5): 262-269.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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