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Abstract
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Article Information:
The Effect of Cis-2-(1H-imidazole-2-yl)-1H-imidazole Dichloro Platinum (II) on the in-vitro Formation of β-Hematin
Mutaz Akkawi, Amneh Aljazzar, Mohammad Abul Haj and Qassem Abu-Remeleh
Corresponding Author: Mutaz Akkawi
Submitted: January 23, 2012
Accepted: February 22, 2012
Published: April 25, 2012 |
Abstract:
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This study aimed at assessing the effect of two Cis-Dichloro Platinum complexes on the in-vitro
formation of the Malaria pigment. According to World Health Organization, death rates of Malaria decreased
by 20%, even with this decrease Malaria is still considered to be the leading killer in Africa. Reports show
nearly 90% of children die before they have the chance to reach their fifth year. Plasmodium; the Malaria
parasite, forms during its intra-erythrocytic stage a pigment called Hemozoin. This pigment acts as a protection
shield against oxygen radical-mediated stress that leads to the death of the parasite. Many drugs targeting the
formation of this pigment are still effective such as Chloroquine and Amodaquine, but recently strains of
Plasmodium have gained resistance to such drugs. As an attempt to find new anti-malarial drugs , the potential
inhibitory effect of Cis-Dichloro Platinum complexes such as Cis- 2-(1H-imidazol-2-yl)-1H-imidazole
Dichloro Platinum (II) and Cis-1-methyl-2-(1-methyl-1H-imidazole-2-yl)-1H-imidazole Dichloro Platinum (II)
on Ferriprotoporphyrin IX (FP) biomineralisation was examined. A previously self-developed quantitative in vitro
method was used to detect the efficiency of these two complexes. Results showed that the efficiency of
Cis- 2-(1H-imidazol-2-yl)-1H-imidazole Dichloro Platinum (II) and Cis-1-methyl-2-(1-methyl-1H-imidazole-2-
yl)-1H-imidazole Dichloro Platinum (II) in preventing the formation of β-Hematin were 69.4 and 45%,
respectively. The efficiency of Chloroquine as a standard drug using the same method was reported to give 95.9%.
Key words: Antimalarial drugs, chloroquine, cis-Dichloro platinum complexes, ferriprotoporphyrin (IX), hemozoin, ,
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Cite this Reference:
Mutaz Akkawi, Amneh Aljazzar, Mohammad Abul Haj and Qassem Abu-Remeleh, . The Effect of Cis-2-(1H-imidazole-2-yl)-1H-imidazole Dichloro Platinum (II) on the in-vitro Formation of β-Hematin. British Journal of Pharmacology and Toxicology, (2): 65-69.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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