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Abstract
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Article Information:
Effects of Tahitian Noni Juice on Ketamine Anaesthesia in Some Local Rabbits
N.O. Bayo, O.D. Eyarefe and R.O.A. Arowolo
Corresponding Author: Eyarefe O. David
Submitted: 2010 July, 19
Accepted: 2010 August, 15
Published: 2010 November, 15 |
Abstract:
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Tahitian Noni Juices (TNJ) from Morinda citrifolia is known with some therapeutic properties that
include; anxiety and stress relief, production of calm and relax state, improvement of mood and sense of well
being, and sleep restoration. This study attempt to evaluate TNJ effects in some ketamine sedated local rabbits.
Six adult rabbits (1.5-1.7 kg) were given intramuscular injection of 5% ketamine hydrochloride (40 mg/kg),
following which the quality of sedation w as evaluated using: muscle relaxation/rigidity, presence or loss of pain
sensation, quality of amnesia as well as heart rate, respiratory rate and temperature as control values. TNJ was
administered orally at 2 mL/kg twice daily for 28 days during which period ketamine injection was repeated
at 7 days interval. Presence of muscle relaxation or rigidity, presence or absence of pain sensation, quality of
amnesia as well as heart rate, respiratory rate and temperature were evaluated. Duration of sleep before and
after noni administration was 40.7±9.6 and 46.8±13.7 min, respectively. There was improved quality of amnesia
and behavioral responses. Rough induction and recovery gave way to smooth induction and recovery, and
spontaneous movement during anesthesia was minimized. Salivation w as abolished in all except one rabbit.
Mean basal heart rate before and after administration of noni were 204.8±48.4 and 264.4±35.6 beats per min,
respectively. Basal respiratory rate also increased from 192±46.3 to 317.6±66.4 breaths per min. TNJ produced
appreciable level of calmness, muscle relaxation, and loss of anxiety, and could be useful for premedication
prior to aneasthesia.
Key words: Ketamine anaesthesia, local rabbits, tahitian noni juices, , , ,
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Cite this Reference:
N.O. Bayo, O.D. Eyarefe and R.O.A. Arowolo, . Effects of Tahitian Noni Juice on Ketamine Anaesthesia in Some Local Rabbits. British Journal of Pharmacology and Toxicology, (2): 81-84.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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