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Abstract
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Article Information:
Protective Effect of Cinnamomum tejpata on Lipid Peroxide Formation in Isolated Rat Liver Homogenate
Vandana Gupta and Mukta Sharma
Corresponding Author: Vandana Gupta
Submitted: 2010 May, 01
Accepted: 2010 May, 27
Published: 2010 July, 20 |
Abstract:
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Restrictions on the use of synthetic antioxidants are being imposed because of their toxic properties.
The present study is the continuation of a program aimed at investigation on antioxidant activity of extracts
from medicinal plants and to identify alternative natural and safe sources of food antioxidant especially from
plant origin. Free radicals are involved in more than 50 diseases. Day to day researchers are adding more
number of diseases to the list. In this report the anti-peroxidative effect of alcoholic extract of Cinnamomum
tejpata has been studied in rat liver homogenate. Ferrous sulphate has been used as inducer to induce lipid per
oxidation. On the basis of results, it could be concluded that TBARS production in normal condition group is
very slow and in FeSO4 treated groups, it is very high. Initiation of lipid peroxidation by ferrous sulphate takes
place either through ferryl- perferryl com plex or through OH Radical from Fenton’s reaction. Effect of different
concentrations of ferrous sulphate for induction of lipid peroxidation in rat liver homogenate was studied. Dose
dependent increase in lipid peroxidation was found. Results revealed that at lower doses the rate of formation
of TBARS is slow , which increased with dose. Significant and moderate results were found from 0.40 mM to
0.80 mM of ferrous sulphate.
Key words: Anti-peroxidative effect, cinnamomum tejpata, ferryl- perferryl complex, lipid peroxidation, TBARS production, ,
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Abstract
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Cite this Reference:
Vandana Gupta and Mukta Sharma, . Protective Effect of Cinnamomum tejpata on Lipid Peroxide Formation in Isolated Rat Liver Homogenate. Current Research Journal of Biological Sciences, (4): Page No: 246-249.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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