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Abstract
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Article Information:
Comparative Genomic Analysis and Evolutionary Study of CD4 Antigen
Liaqat Ali, Muhammad Ilyas, Syed Saleem Shah, Muhammad Ali, Syed Muhammad Ibrahim, Shakeel Ahmad and Inamullah
Corresponding Author: Muhammad Ilyas
Submitted: 2009 December, 23
Accepted: 2010 January, 06
Published: 2010 September, 2010 |
Abstract:
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CD4 antigen is important to act as the primary receptor for the HIV. In order to understand the
human CD4 gene and to determine its evolutionary aspects, we characterized this gene in detail in six different
organisms. A comparative study was made of nucleotide length variations, intron and exon sizes and number
variations, differential compositions of coding to non-coding bases, etc., to look for similarities/dissimilarities
in the CD4 gene across all six taxa. Phylogenetic analysis showed the pattern found in other genes, as Homo
sapiens and Pan troglodytes were placed in a single clade, and Rattus norvegicus and Mus musculus in another.
We further focused on the two primates and aligned the amino acid sequences; there were small differences
between humans and chimpanzees; both w ere more different from the other organisms.
Key words: CD4 antigen, CpG islands, genomics, Homo sapiens, Pan troglodytes, phylogentics,
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Cite this Reference:
Liaqat Ali, Muhammad Ilyas, Syed Saleem Shah, Muhammad Ali, Syed Muhammad Ibrahim, Shakeel Ahmad and Inamullah, . Comparative Genomic Analysis and Evolutionary Study of CD4 Antigen. Current Research Journal of Biological Sciences, (5): Page No: 328-332.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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