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Abstract
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Article Information:
Antioxidant Effect of Ethanolic Seed Extract of Hibiscus sabdariffa linn (Malvaceae) Alleviate the Toxicity Induced by Chronic Administration of Sodium Nitrate on Some Haematological Parameters in Wistars Rats
I.G. Bako, M.A. Mabrouk and A. Abubakar
Corresponding Author: IBRAHIM BAKO GAYA
Submitted: 2009 Sept., 20
Accepted: 2009 Oct., 02
Published: |
Abstract:
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The antioxidant activity of ethanolic seed extract of Hibiscus sabdariffa l. was investigated in
toxicity induced by chronic administration of sodium nitrate in wistar rats. Twenty-five adult wistar rats were
randomly grouped into 5 groups of five rats in each group (n=5). Group I (normal saline); Group II (25mg/kg
NaNO3); Group III (25mg/kg NaNO3 + 10mg/kg vitamin C); Group IV (25mg/kg NaNO3 +100mg/kg HS); and
Group V (25mg/kg NaNO3 + 200mg/kg HS). All groups received normal saline, Vitamin C and sodium nitrate
daily for 60 days respectively. The animals were sacrificed at end of 60 days and blood samples were taken for
analysis of total protein and some haematological indices. The toxicity induced by chronic administration of
NaNO3 seems to be alleviated by the antioxidant effect Hibiscus sabdariffa l. Tocopherol (Vitamin E) and
ascorbic acid (Vitamin C) may likely be responsible for the antioxidant effect of Hibiscus sabdariffa l. since
preliminary phytochemical screening reveal the presences of substantial amount in seed oil. Hibiscus sabdariffa
l. seed extract are characterized by a very low degree of toxicity with LD50 of above 5000 mg/kg in rats.
Key words: Antioxidant, ethanolic, Sodium nitrate, Hibiscus sabdariffa , toxicity, ,
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Cite this Reference:
I.G. Bako, M.A. Mabrouk and A. Abubakar, . Antioxidant Effect of Ethanolic Seed Extract of Hibiscus sabdariffa linn (Malvaceae) Alleviate the Toxicity Induced by Chronic Administration of Sodium Nitrate on Some Haematological Parameters in Wistars Rats. Advance Journal of Food Science and Technology, (1): Page No: 39-42.
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ISSN (Online): 2042-4876
ISSN (Print): 2042-4868 |
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