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Abstract
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Article Information:
Evaluation of Ghrelin Levels in Polycystic Ovary Syndrome and the Correlation with Obesity, Insulin Resistance and Other Biochemical Features
Kun Shi ,Balsam Habeeb Jasim and Xuecheng Shao
Corresponding Author: Balsam Habeeb
Submitted: 2011 August, 08
Accepted: 2011 September, 14
Published: 2011 October, 25 |
Abstract:
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Ghrelin is new peptide might be associated with common features of polycystic ovary syndrome
(PCOS) like insulin resistance and adiposity. Irregularities of ghrelin levels in PCOS contributed to the many
physiological problems as (obesity and energy balance). The purpose of this work was to evaluate the ghrelin
levels in women with polycystic ovary syndrome and control and secondarily assessed the correlation of ghrelin
levels with obesity and insulin resistance. Serum ghrelin levels were compared between 57 Chinese women
have PCOS were divided into two groups according to their body mass index (BMI): 30 overweight/obese
PCOS and 27 non obese PCOS and 20 healthy controls. The correlation between ghrelin levels and other
hormones was investigated. Anthropometric measurements were made for all subjects. Biochemical and
hormonal investigations included plasma glucose, insulin, luteinizing hormone (LH), follicle-stimulating
hormone (FSH), estradiol (E2), testosterone and insulin resistance was measured by using Homeostasis Model
of Assessment of Insulin Resistance (HOMA-IR). Serum ghrelin levels were measured by Enzyme Linked
Immunosorbent Assay (ELISA) method. Plasma ghrelin levels were significantly decreased in overweight/obese
PCOS compared to non-obese PCOS and control group. Fasting insulin levels and HOMA-IR were significantly
higher in theoverweight/obese group compared to control. Significant inverse correlation was observed between
ghrelin levels and BMI in both overweight/obese PCOS and control (r = -0.71, p<0.05; r = -0.61, p<0.05).
There were not any correlations between ghrelin levels and other parameters like HOMA-IR, LH, FSH, E2 and
testosterone in PCOS were observed. The findings of this study propose that plasma ghrelin levels were found
to be lower in PCOS than control and negatively correlated with BMI. It is a new marker that may be used for
diagnosis of PCOS.
Key words: Body mass index, ghrelin, homeostasis model assessment, polycystic ovarian syndrome, , ,
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Abstract
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Cite this Reference:
Kun Shi ,Balsam Habeeb Jasim and Xuecheng Shao, . Evaluation of Ghrelin Levels in Polycystic Ovary Syndrome and the Correlation with Obesity, Insulin Resistance and Other Biochemical Features. Asian Journal of Medical Sciences, (5): 218-222.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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