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Abstract
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Article Information:
Simultaneous Treatment of Cancer Cells Lines with the Anticancer Drug Cisplatin and the Antioxidant Fucoxanthin
Takeshi Mise and Takeshi Yasumoto
Corresponding Author: Takeshi Mise
Submitted: 2011 April, 10
Accepted: 2011 May, 13
Published: 2011 August, 05 |
Abstract:
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The anti-oxidative properties and the other health benefits of fucoxanthin (Fx) make it a good
candidate for a health food supplement. However, the use of antioxidant supplements in patients undergoing
chemotherapy has been widely debated because of concerns that the antioxidants may interfere with the
mechanisms of the anticancer drugs. To investigate this concern, we studied the effect of Fx on the anticancer
drug cisplatin. Fucoxanthinol (Fxol), which is a deacetylated product produced during intestinal absorption,
and other antioxidants (fucoxanthin acetate, astaxanthin, and "-tocopherol) were also included in the
experiments. Both Fx and Fxol suppressed the proliferation of cultured cancer cells (Caco-2, Hep G2, and
Neuro2a) in a dose-dependent manner, whereas the other antioxidants showed no evident effect on their growth.
Moreover, when added to a medium containing cisplatin, none of the studied antioxidants mitigated the
inhibitory growth effects of cisplatin. Our results suggested that intake of Fx may help to prevent cancer and
that it may not interfere with the mechanisms of anticancer drugs during chemotherapy. However, further
studies, using animal models in particular, are required to elucidate these interactions.
Key words: Anticancer agent, carotenoid, fucoxanthinol, , , ,
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Abstract
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Cite this Reference:
Takeshi Mise and Takeshi Yasumoto, . Simultaneous Treatment of Cancer Cells Lines with the Anticancer Drug Cisplatin and the Antioxidant Fucoxanthin. British Journal of Pharmacology and Toxicology, (3): 127-131.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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