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Abstract
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Article Information:
Anti-inflammatory Effects of the Aqueous Extracts of Plantain Roots (Musa Species)
A.O. Ibegbu, U.J. Okonji, W.O. Hamman, U.E. Umana, D.T. Ikyembe and S.A. Musa
Corresponding Author: A.O. Ibegbu
Submitted: February 21, 2012
Accepted: March 16, 2012
Published: April 15, 2012 |
Abstract:
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The ant-inflammatory effects of the aqueous extracts of plantain (Musa Species) roots was
investigated using egg albumin-induced inflammation on the hind-paw in 45 adult Wistar rats. The animals
were grouped into nine groups of five rats each. The first group was administered with normal saline while the
second group was given a standard anti-inflammatory drug. Piroxicam 20 mins before induction of
inflammation. The third, fourth and fifth groups were administered with the different concentrations of the
Plantain root extracts 20 min before induction of inflammation while the sixth group was induced with
inflammation 20 min before the administration of the standard drug (Piroxicam). The seventh, eighth and ninth
groups were administered with different concentrations of the Plantain root extracts 20 min after the egg
albumin induced inflammation to investigate the effects of the different concentrations of the Plantain root
extracts on the size of the hind-paw induced inflammation on the rats. Measurements of the sizes of the
inflammation were done every 20 min for 3 h. The results showed significant reduction in the sizes of the
inflammation in both the administration of the extracts before and after the induction of inflammation which
was found to be dose and time dependent. These results compared favorably with the conventional antiinflammatory
drugs and show that the aqueous extracts of Plantain roots can be effective as a protective and
treatment agent against inflammatory conditions and diseases.
Key words: Egg albumin, hind paw, inflammation, piroxicam, plantain root, wistar rats,
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Cite this Reference:
A.O. Ibegbu, U.J. Okonji, W.O. Hamman, U.E. Umana, D.T. Ikyembe and S.A. Musa, . Anti-inflammatory Effects of the Aqueous Extracts of Plantain Roots (Musa Species). British Journal of Pharmacology and Toxicology, (2): 70-75.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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