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Abstract
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Article Information:
Extended Immunization of Rats using Microencapsulated Cobra Venom
H.F. Salem, Aly Fahmy and Ahmed M.A. Ali
Corresponding Author: Heba F. Salem
Submitted: 2011 June, 11
Accepted: 2010 July, 22
Published: 2011 February, 10 |
Abstract:
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Production of a vaccine with an extended release kinetic and with a high immunization response has
an economic value in the third world countries. In this study, production and evaluation of bovine serum
albumin microspheres that are incorporating cobra venom were carried out. The microcapsules were prepared
using modified emulsification-polymerization technique. They were evaluated for their size using photon
correlation spectroscopy and for their morphology using scanning electron microscopy. The release kinetics
of the venom from the chosen formula was following Higushi model with r2 >0.97. The average microsphere
size of the best formula was 5.6 :m and the encapsulation efficiency approached 82%. The pharmacokinetic
parameters of the microencapsulated cobra venom showed a significant difference from the free venom
formulations in terms o f prolonged stimulation of in-vivo immune response (production of antibodies). The
method of preparation and evaluation of microspheres were characterized by being easy to perform, yielding
high entrapment efficiency and maximum induction of immune response, which enables availability of a safe,
effective and economic vaccine.
Key words: BSA, Copra venom, ELISA, microspheres, sustained release, ,
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Abstract
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Cite this Reference:
H.F. Salem, Aly Fahmy and Ahmed M.A. Ali, . Extended Immunization of Rats using Microencapsulated Cobra Venom. British Journal of Pharmacology and Toxicology, (1): 43-50.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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