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Abstract
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Article Information:
Synergistic Effects of Antioxidant Vitamins on Lipid Profile in Pregnancy
O.I. Iribhogbe, J.E. Emordi, B.O. Idonije, A. Aigbiremolen, E.O. Nwoke and U. Akpamu
Corresponding Author: Osede Ignis Iribhogbe
Submitted: 2010 October, 11
Accepted: 2010 November, 15
Published: 2011 March, 05 |
Abstract:
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This study was designed to investigate the significance of varying combination of vitamin A, C and
E on lipidemic profile in pregnancy. In a bid to achieve this task, 70 female Wister rats weighing between 250-
300 g were procured and grouped into 2 control groups treated with distilled H2O and vehicle, tween-80
respectively and three cohorts (I, II and III) with four sub-groups (n = 5). Pregnancy was confirmed on the 6th
day after mating with male Wister rats, after which group I received a combination of vitamin A and C, group
II- vitamin A and E and group III- vitamin C and E respectively for 11 days. Results revealed a significant
(p<0.05) increase in HDL-C in the entire combination group, which was dose dependent. This was more
prominent in group II (vit A + E). Although, there were reductions in serum cholesterol (CHO), serum
triglyceride (TRI) and LDL-C levels, this was not significant (p>0.05). In conclusion, the synergetic potential
of antioxidant vitamin combination appears beneficial in the management of pregnancy related hyperlipedemic
states.
Key words: Antioxidants, hyperlipidemia, pregnancy, synergistic effect, vitamins, ,
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Cite this Reference:
O.I. Iribhogbe, J.E. Emordi, B.O. Idonije, A. Aigbiremolen, E.O. Nwoke and U. Akpamu, . Synergistic Effects of Antioxidant Vitamins on Lipid Profile in Pregnancy. Current Research Journal of Biological Sciences, (2): 104-109.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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