Home            Contact us            FAQs
    
      Journal Home      |      Aim & Scope     |     Author(s) Information      |      Editorial Board      |      MSP Download Statistics

     Asian Journal of Medical Sciences

    Abstract
2011(Vol.3, Issue:2)
Article Information:

Antidepressant Effects of Noni Fruit and its Active Principals

Shixin Deng and Brett J. West
Corresponding Author:  Shixin Deng 
Submitted: 2011 February, 24
Accepted: 2011 March, 26
Published: 2011 April, 20
Abstract:
The antidepressant effects of Morinda citrifolia (noni) fruit extracts were investigated in vitro with the Monoamine Oxidase (MAO) A and B bioassays. The ethyl acetate extract of freeze-dried noni fruit powder inhibited MAO-A and B enzymes 78 and 49%, respectively. A phytochemical study of the most active extract led to the isolation of nine compounds. Among these, three principles including two flavonoids, kaempferol and quercetin, as well as one lignan, (+)-3,4,3',4'-tetrahydro-9,7'α-epoxylignan-7α,9'-lactone, were found to be potent MAO-A and B inhibitors. These findings indicate that noni fruit is a natural MAO-A and MAO-B inhibitor, involving a synergistic effect from multiple active components.

Key words:  Active compounds, antidepressant, MAO-A & B, Morinda citrifolia, noni, ,
Abstract PDF HTML
Cite this Reference:
Shixin Deng and Brett J. West, . Antidepressant Effects of Noni Fruit and its Active Principals. Asian Journal of Medical Sciences, (2): 79-83.
ISSN (Online):  2040-8773
ISSN (Print):   2040-8765
Submit Manuscript
   Information
   Sales & Services
Home   |  Contact us   |  About us   |  Privacy Policy
Copyright © 2024. MAXWELL Scientific Publication Corp., All rights reserved