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Abstract
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Article Information:
Study of the Effect of Aqueous Extract of Kolanut (Cola nitida) on Gastric Acid Secretion and Ulcer in White Wistar Rats
J.A.Tende, I. Ezekiel, S.S. Dare, A.O. Okpanachi, S.O. Kemuma and A.D.T. Goji
Corresponding Author: Ezekiel Iliya
Submitted: 2011 May, 04
Accepted: 2011 May, 27
Published: 2011 August, 05 |
Abstract:
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Generally, increase in the acid output in the body causes ulcer especially peptic ulcer. Duodenal ulcer
has worldwide incidence but its incidence varies geographically and even in some country regionally. Duodenal
and peptic ulcer diseases are problems of the gastrointestinal tract. Nowadays, drugs are expensive and have
many side effects during treatment of any disorders. In this study the aqueous extract of cola nitida was
administered to 30 Wistar rats in two phases (gastric acid secretion phase and ulceration phase). The ulcer score
and gastric acidity were determined. The highest acid output was obtained with a dose of 7.5 mg/mL and the
lowest with a dose of 5.0 mg/mL. However no ulceration was seen with the same doses of cola nitida, this may
mean that formation of ulcerations may not be only due to increase acidity or probably the doses used was not
enough to cause ulceration. Comparing this with control group gave a significant difference for the gastric acid
secretion group, though there was no ulceration formed with the same dose. The result of this study showed
that cola nitida induces gastric secretion.
Key words: Caffeine, cola nitida, duodenal, gastric secretion, peptic ulcer, xanthine,
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Cite this Reference:
J.A.Tende, I. Ezekiel, S.S. Dare, A.O. Okpanachi, S.O. Kemuma and A.D.T. Goji, . Study of the Effect of Aqueous Extract of Kolanut (Cola nitida) on Gastric Acid Secretion and Ulcer in White Wistar Rats. British Journal of Pharmacology and Toxicology, (3): 132-134.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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