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Abstract
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Article Information:
Behavioural Enpoints of Adult Wistar Rats, Following Aluminium Chloride Exposure
A.A. Buraimoh, S.A. Ojo, J.O. Hambolu and S.S. Adebisi
Corresponding Author: Buraimoh Adebayo Adekunle
Submitted: 2011 September, 09
Accepted: 2011 September, 30
Published: 2011 November, 25 |
Abstract:
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Aluminium is a ubiquitous element and the third most abundant element in the earth's crust,
comprising approximately 8% of the earth’s crust, exceeded only by oxygen (47%) and silicon (28%).The
elemental aluminium does not occur in its pure state but is always combined with other elements such as
chloride, hydroxide, silicate, sulphate and phosphate. Patients on dialysis or on long-term treatment with total
parenteral nutrition have been shown to accumulate this metal in different organs. The Morris Water Maze
(MWM) was described as a device to investigate spatial learning and memory as well as tools in behavioural
neuroscience. The objective of this study was to determine the behavioural endpoints of wistar rats, following
the aluminium chloride exposure. Total of thirty wistar rats were used in this study. The wistar rats were divided
into five groups; group I was the control, group II received 475 mg/kg, group III received 950 mg/kg, group
IV received 1,425 mg/kg and group V received 1,900 mg/kg via oral intubation for a duration of Eight
weeks.MWM was used to test for the behaviour of the wistar rats. We observed that at the first run, the wistar
rats were trying to learn task; the second and third runs rather showed that wistar rats in the control group get
to the platform faster (performed the task better) than the treated groups and the difference observed was
significant at p<0.05.We therefore conclude that Aluminium chloride exposure has negative effects on
behavioural endpoints and can impair learning and memory.
Key words: Adult, aluminium chloride, behavioural endpoints, exposure, wistar rats, ,
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Cite this Reference:
A.A. Buraimoh, S.A. Ojo, J.O. Hambolu and S.S. Adebisi, . Behavioural Enpoints of Adult Wistar Rats, Following Aluminium Chloride Exposure. British Journal of Pharmacology and Toxicology, (5): 273-276.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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