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Abstract
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Article Information:
In vitro Antiplasmodial Activity of Some Medicinal Plants Used in Folk Medicine in Burkina Faso Against Malaria
Cheikna Zongo, Lamoussa Paul Ouattara, Aly Savadogo, Souleymane Sanon, Nicolas Barro, Jean Koudou, Issa Nebie and Alfred S. Traore
Corresponding Author: Cheikna Zongo
Submitted: 2011 February, 10
Accepted: 2011 March, 15
Published: 2011 May, 05 |
Abstract:
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The aim of this study was to evaluate the in vitro antiplasmodial activities of four plants used in
traditional medicine. Hydroethanolic extract, hydroacetonic extract and aqueous extract of Mitragyna inermis
(Willd.) O. Kuntze (Rubiaceae), Combretum sericeum G. Don (Combretaceae), Alternanthera pungens H.B.
and K (Amaranthaceae) and Ampelocissus grantii (Baker) Planch (Vitaceae) have been tested in vitro against
chloroquine-resistant strain (K1) and chloroquine-sensitve strain (3D7) of Plasmodium falciparum using pLDH
assay. Aqueous extracts exhibited the best results against K1 with the 50% inhibitory concentration (IC50)
values of 0.54±0.18, 1.72±0.99, 1.54±0.04 μg/mL for respectively, M. inermis leaves, C. sericeum leaves and
whole plant of A. pungens. Hydroethanolic extract from the leaves of M. inermis gave also IC50 value of
0.87±0.10 μg/mL with 3D7. Extracts showed antiplasmodial activity against both chloroquine-sensitive and
chloroquine-resistant P. falciparum strains. Our study justifies the use of these plants in traditional medicine
and leads to further investigations.
Key words: Crude extracts, malaria, medicinal plants, Plasmodium falciparum, pLDH assay, ,
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Cite this Reference:
Cheikna Zongo, Lamoussa Paul Ouattara, Aly Savadogo, Souleymane Sanon, Nicolas Barro, Jean Koudou, Issa Nebie and Alfred S. Traore, . In vitro Antiplasmodial Activity of Some Medicinal Plants Used in Folk Medicine in Burkina Faso Against Malaria. Current Research Journal of Biological Sciences, (3): 216-222.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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