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Abstract
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Article Information:
Risk Factors for Congenital Heart Disease (CHD) in Vellore, India
Anshula Tandon, Sonali Sengupta, Vinayak Shukla and Sumita Danda
Corresponding Author: Anshula Tandon
Submitted: 2010 May, 15
Accepted: 2010 May, 27
Published: 2010 July, 20 |
Abstract:
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The aim of this study was to investigate the probable risk factors implicated in the aetiology of
Congenital Heart Disease (CHD) in Vellore population, India. CHD is now a most common cause of birth
defects. The burden of CHD in India is enormous due to very high birth rate. This emphasizes the importance
of this group of heart diseases. The cause of 90% of the CHDs is multifactorial, but little is known about the
environmental risk factors. Thus a matched case control study was conducted in Vellore, India, aiming at
investigating the risk factors responsible for the causation of CHDs. Descriptive statistics was reported as mean
value and 95% Confidence Interval (CI). Chi-square (χ²) test was used for testing the association between two
variables. Univariate analysis was performed followed by multivariate logistic regression analysis to provide
the estimated effect of each risk factor. Thus Chi-square (χ²) test showed that significant risk factors that are
associated with CHDs were maternal and paternal age at pregnancy, rural residence, birth order, birth weight
of the individual, consanguineous marriages, family history of inherited disorder, maternal drug exposure,
maternal illness, maternal infection, socio-economic status of the family. Logistic regression analysis revealed
that only maternal and paternal age at pregnancy, rural residence, birth order and birth weight of the individual
were only found significantly associated in the development of CHDs. This study emphasizes on the
augmenting pre-marital counselling and regular health counselling during pregnancy, extending health
education to women of childbearing age and need of occupational health system to monitor the residential areas
for risk of any environmental teratogen.
Key words: Chi-square (χ²), Congenital Heart Disease (CHD), multivariate logistic regression, risk factors, univariate analysis, ,
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Abstract
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Cite this Reference:
Anshula Tandon, Sonali Sengupta, Vinayak Shukla and Sumita Danda, . Risk Factors for Congenital Heart Disease (CHD) in Vellore, India. Current Research Journal of Biological Sciences, (4): Page No: 253-258.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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