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Abstract
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Article Information:
Acute Exposure to Artesunate and its Effect on the Hematological Indices, Hepatotoxicity And Histology of The Liver of Adult Wistar Rats
Wilson O. Hamman, Sunday A. Musa, Fareha Muzaffar, Sabdat O. Sani, Uduak E. Umana, James A. Timbuak, Andrew J. Nok and Samuel A. Ojo
Corresponding Author: Wilson Oliver Hamman
Submitted: 2011 June, 27
Accepted: 2011 August, 27
Published: 2011 August, 30 |
Abstract:
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The effect of artesunate on the hematological indices, hepatotoxicity and histology of liver was
investigated in 20 adult male wistar rats. The animals were divided into 4 groups of 5 each and group 1 which
served as control were administered normal saline while groups 2, 3 and 4 were administered 1, 2 and
5 mg per kg/day respectively for a period of 5 days. The animals were humanely sacrificed on the sixth day and
blood samples were obtained for hematological indices and serum enzyme analysis. The liver were excised
and processed for light microscopy using the H & E stain. Hematological indices indicated insignificant
difference in the RBC, WBC and DC counts, while a significant dose dependent increase in PCV and
hemoglobin were observed (p<0.05). No changes were observed in the serum levels of Aspartate
Aminotransferase (AST), Alanine Aminotransferase (ALT) and Alkaline Phosphatase (ALP) among the groups.
Histological examination of the liver revealed points of focal necrosis among the treated groups. The mild liver
tissue damage was more evident among the over dosed group. Artesunate is thus safe, when administered
within the therapeutic range.
Key words: Artesunate, hepatotoxicity, hematological indices, histology, liver, ,
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Cite this Reference:
Wilson O. Hamman, Sunday A. Musa, Fareha Muzaffar, Sabdat O. Sani, Uduak E. Umana, James A. Timbuak, Andrew J. Nok and Samuel A. Ojo, . Acute Exposure to Artesunate and its Effect on the Hematological Indices, Hepatotoxicity And Histology of The Liver of Adult Wistar Rats. Asian Journal of Medical Sciences, (4): 176-179.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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