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Abstract
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Article Information:
Protective Effect of Allium sativum against Liver Injury Induced by Anti-Tubercular Drugs in Rats
B. Bello and A.M. Wudil
Corresponding Author: B. Bello
Submitted: February 29, 2012
Accepted: March 16, 2012
Published: April 25, 2012 |
Abstract:
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Allium sativum has been reported to have a lot of therapeutic potentials such as antihypertensive,
antimicrobial and hypocholesterolemic. This study has investigated its effect on anti-tubercular drugs
hepatotoxicity. Wistar albino rats were pretreated and co-administered orally with aqueous solution of Allium
sativum. Eighteen rats were divided into six groups of three rats each. Group 1 were normal, while Group 2
were test control administered with anti-tubercular drugs; isoniazid (27 mg/kg bw) and rifampicin (54 mg/kg
bw). Groups 3 and 4 were pretreated with 100 and 200 mg/kg of Allium sativum for 28 days, then administered
with isoniazid and rifampicin at doses 27 and 54 mg/kg respectively for same duration. In groups 5 and 6, same
doses of Allium sativum and anti-tubercular drugs were administered concurrently for twenty eight days. Serum
levels of Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Alkaline Phosphatase (ALP)
and unconjugated bilirubin (uBIL) were estimated 24 h after administration of the last dose. The results showed
that pretreatment and co-administration of Allium sativum solution significantly reduced (p<0.05) serum ALT,
AST and ALP activities and uBIL concentration in the rats, compared to the test control administered with antitubercular
drugs only, to induce liver damage. The results suggest that aqueous extracts of Allium sativum can
be said to have protective effect on anti-tubercular drugs hepatotoxicity in rats.
Key words: Allium sativum, anti-tubercular drugs, hepatotoxicity, isoniazid, liver enzymes, rifampicin,
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Abstract
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Cite this Reference:
B. Bello and A.M. Wudil, . Protective Effect of Allium sativum against Liver Injury Induced by Anti-Tubercular Drugs in Rats. British Journal of Pharmacology and Toxicology, (2): 89-92.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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