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Abstract
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Article Information:
Phytochemical and Anticonvulsant Properties of Annona senegalensis Pers. (Annonaceae), Plant Used in Burkina Folk Medicine to Treat Epilepsy and Convulsions
A. Konate, W.R. Sawadogo, F. Dubruc, O. Caillard, M. Ouedraogo and I.P. Guissou
Corresponding Author: A. Konate
Submitted: August 09, 2012
Accepted: September 03, 2012
Published: October 25, 2012 |
Abstract:
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Annona senegalensis Pers. (Annonaceae) is claimed in traditional medicine in Burkina Faso to be useful
in the treatment of epilepsy. The present study aimed to investigate the phytochemical and pharmacological
properties of the aqueous extracts of its root bark. The phytochemical analysis was performed using standard tests
according to the Ciulei method. The acute toxicity was carried out in rats and the effect of aqueous extract on the
pilocarpine and picrotoxin induced seizure in mice and rats were investigated by curative and preventive modes. The
phytochemical screening showed the presence of alkaloids, terpinoids and saponins in the aqueous extract of
Annona senegalensis root bark. The intraperitoneal median lethal dose (LD50) was found to be more than 3000
mg/kg in rats. The curative treatment induced a significant decrease of the intensity of the seizure caused by
peritoneal injection of pilocarpine in the treated mice when compared to the negative controls. Time put to inhibit 50
% of the seizures by the plant extract was 16 min at the dose of 150 mg/kg against 14 min for standard diazepam (2
mg/kg). In preventive mode, the plant extract prolonged the latency of convulsions. These results suggest that the
root bark of Annona senegalensis may possess anticonvulsant properties in rodents.
Key words: Anticonvulsant, picrotoxin, pilocarpine, preventive, scopolamine, treatment,
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Abstract
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Cite this Reference:
A. Konate, W.R. Sawadogo, F. Dubruc, O. Caillard, M. Ouedraogo and I.P. Guissou, . Phytochemical and Anticonvulsant Properties of Annona senegalensis Pers. (Annonaceae), Plant Used in Burkina Folk Medicine to Treat Epilepsy and Convulsions. British Journal of Pharmacology and Toxicology, (5): 245-250.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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