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Abstract
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Article Information:
The Evaluation of Neuraminidase Type 2 Models
Sigit Jaya Herlambang and Rosari Saleh
Corresponding Author: Sigit Jaya Herlambang
Submitted: 2011 February, 10
Accepted: 2011 March, 21
Published: 2011 May, 05 |
Abstract:
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The aim of this study is to predict a model with the smallest errors by comparing built homology
models using three different methods instead of using just one method. The generated models from building
homology models always contain errors. The outcomes with smaller errors are the best models to be used for
further study. The combination of three methods resulted in the determination of one model, the model no. 2,
which is better than the other constructed models. The DOPE score of this model was -36613.3 which held the
4th place in DOPE score rank and the score from profiles-3D was 195.05 which was the best in the verify score
rank. The online protein models assessment PROCHECK results showed that 98.8% residues (without Pro and
Gly) of this model are in the most favoured and additional allowed regions. The results show that the three
methods used, may help to select a better model to be simulated by considering different perspectives than if
we choose a model with only one method perspective.
Key words: Homology modeling, influenza, model assessment, neuraminidase, , ,
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Cite this Reference:
Sigit Jaya Herlambang and Rosari Saleh, . The Evaluation of Neuraminidase Type 2 Models. Current Research Journal of Biological Sciences, (3): 223-228.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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