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Abstract
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Article Information:
Effect of Ethanol Extract of Sesamum indicum Seeds on Lipid Profile in vivo
Noor Ali Ghani, Muayad S. Shawkat and Mahfoodha A. Umran
Corresponding Author: Muayad S. Shawkat
Submitted: 2011 November, 01
Accepted: 2011 November, 25
Published: 2012 March, 10 |
Abstract:
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The present study was conducted to investigate the effect of active compound (sesamin) found in
defatted ethanol extract of Sesamum indicum seeds on the serum levels of lipid in mice. The qualitative and
quantitative determination of sesamin bioactive compound in defatted ethanol extract using High Performance
Liquid Chromatography (HPLC) analysis was carried out and compared with standard sesamin. It was found
that the concentration of sesamin was 79.9% of ethanolic extract according to total peak area. The ffect of active
compound (sesamin) in defatted ethanol sesame extract was evaluated in mice blood serum (in vivo) after
feeding them high and low fat diet for one month. Defatted Sesame extract at concentration 500 mg/kg of body
weight (B.W) showed significant reduction (p#0.05) in the level of total cholesterol (62.26 , 56.14) mg/dl,
triglycerides (61.54 , 61.12) mg/dl , and low density lipoprotein LDL (29.97 , 23.21) mg/dl and significant
increase in the level of high density lipoprotein HDL (19.39 , 20.70) mg/dl in comparison with both high and
low fat diet groups which recorded (80.43 , 68.24) mg/dl, (77.50 , 74.16) mg/dl, (16.80 , 19.32) mg/dl, and
(48.09 , 34.08) mg/dL, respectively.
Key words: HDL, HPLC, LDL, Lipid profile, Sesamum indicum, sesame extract,
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Cite this Reference:
Noor Ali Ghani, Muayad S. Shawkat and Mahfoodha A. Umran, . Effect of Ethanol Extract of Sesamum indicum Seeds on Lipid Profile in vivo. Current Research Journal of Biological Sciences, (2): 159-163.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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