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Abstract
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Article Information:
Biochemical and Histologic Effect of Dietary Substitution with Solvent Extracted Neem Seed Cake of Albino Rats (wistar strain)
D.B James, D.A Ameh , A.S Agbaji and N. D.G Ibrahim
Corresponding Author: Dorcas B James
Submitted: 2009 June, 06
Accepted:
Published: |
Abstract:
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The performance of 20 albio rats (wistar strain) ages 3 weeks was investigated by feeding neem seed
cake (NSC) after treatment with solvents. Group 1 and those of group II and III were fed experimental diets
containing water, 75% methanol and 75% ethanol processed neem seed cake respectively as a replacement for
soya bean for a period of 28days. Replacement of soya bean by water processed neem seed depressed the
growth at the end of 4th week while for the other solvent processing 4th week was a period of stunted growth.
There was no significant (p>0.05) difference in the PCV and Hb of animals fed MNSC diet compared to
animals fed with standard protein diet. All the animals fed with processed neem seed cakes showed significant
(p<0.05) increases in serum albumin compared to standard. Of all the serum marker enzymes determ ined only
the level of SGOT for animals fed with ethanol processed neem seed cake was significantly (p<0.05) higher
and the histopathology studies revealed fatty degeneration and necrosis of hepatic tissue and glomerular and
renal necrosis compared to the standard feed and other solvents treated.
Key words: Neem seed, Processd cake, Substitution, Solvent extraction, Albino rats, ,
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Cite this Reference:
D.B James, D.A Ameh , A.S Agbaji and N. D.G Ibrahim, . Biochemical and Histologic Effect of Dietary Substitution with Solvent Extracted Neem Seed Cake of Albino Rats (wistar strain). International Journal of Animal and Veterinary Advances, (1): Page No: 1-5.
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ISSN (Online): 2041-2908
ISSN (Print): 2041-2894 |
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